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タイトル: | The gene regulatory system for specifying germ layers in early embryos of the simple chordate |
著者: | Tokuoka, Miki Maeda, Kazuki Kobayashi, Kenji Mochizuki, Atsushi https://orcid.org/0000-0002-7714-1755 (unconfirmed) Satou, Yutaka https://orcid.org/0000-0001-5193-0708 (unconfirmed) |
著者名の別形: | 徳岡, 三紀 前田, 一貴 小林, 健司 望月, 敦史 佐藤, ゆたか |
発行日: | Jun-2021 |
出版者: | American Association for the Advancement of Science (AAAS) |
誌名: | Science Advances |
巻: | 7 |
号: | 24 |
論文番号: | eabf8210 |
抄録: | In animal embryos, gene regulatory networks control the dynamics of gene expression in cells and coordinate such dynamics among cells. In ascidian embryos, gene expression dynamics have been dissected at the single-cell resolution. Here, we revealed mathematical functions that represent the regulatory logics of all regulatory genes expressed at the 32-cell stage when the germ layers are largely specified. These functions collectively explain the entire mechanism by which gene expression dynamics are controlled coordinately in early embryos. We found that regulatory functions for genes expressed in each of the specific lineages contain a common core regulatory mechanism. Last, we showed that the expression of the regulatory genes became reproducible by calculation and controllable by experimental manipulations. Thus, these regulatory functions represent an architectural design for the germ layer specification of this chordate and provide a platform for simulations and experiments to understand the operating principles of gene regulatory networks. |
記述: | 動物胚の遺伝子発現を数式で表現 --動物の胚葉形成システムをまるごと理解--.京都大学プレスリリース. 2021-06-10. |
著作権等: | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/263315 |
DOI(出版社版): | 10.1126/sciadv.abf8210 |
PubMed ID: | 34108211 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2021-06-10-1 |
出現コレクション: | 学術雑誌掲載論文等 |
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