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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.ultrasmedbio.2021.02.009.pdf | 725.94 kB | Adobe PDF | 見る/開く |
| タイトル: | Low-Intensity Pulsed Ultrasound Prompts Both Functional and Histologic Improvements While Upregulating the Brain-Derived Neurotrophic Factor Expression after Sciatic Crush Injury in Rats |
| 著者: | Wang, Tianshu Ito, Akira    https://orcid.org/0000-0002-9645-9777 (unconfirmed)Xu, Shixuan Kawai, Hideki Kuroki, Hiroshi Aoyama, Tomoki https://orcid.org/0009-0002-5172-5477 (unconfirmed) |
| 著者名の別形: | 伊藤, 明良 河合, 秀樹 黒木, 裕士 青山, 朋樹 |
| キーワード: | Low-intensity pulsed ultrasound Peripheral nerve regeneration Functional improvement Changesover time Brain-derived neurotrophic factor |
| 発行日: | Jun-2021 |
| 出版者: | Elsevier BV |
| 誌名: | Ultrasound in medicine & biology |
| 巻: | 47 |
| 号: | 6 |
| 開始ページ: | 1586 |
| 終了ページ: | 1595 |
| 抄録: | The aim of this study was to determine that low-intensity pulsed ultrasound (LIPUS) at an intensity of 140 mW/cm² promotes functional and histologic improvements in sciatic nerve crush injury in a rat model and to investigate changes over time in relevant growth factors and receptors, exploring the mechanism of LIPUS in the recovery process after injury. Toe angle in the toe-off phase, regenerative axonal length, myelinated nerve fiber density, diameter of myelinated nerve fiber, axon diameter and myelin sheath thickness were significantly higher in the LIPUS group than in the sham group. Gene and protein expression of brain-derived neurotrophic factor (BDNF) was upregulated in the LIPUS group. In conclusion, LIPUS contributed to rapid functional and histologic improvement and upregulated BDNF expression after sciatic nerve crush injury in rats. |
| 著作権等: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 June 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/263336 |
| DOI(出版社版): | 10.1016/j.ultrasmedbio.2021.02.009 |
| PubMed ID: | 33745752 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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