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dc.contributor.author | Oyama, Kei | en |
dc.contributor.author | Hori, Yukiko | en |
dc.contributor.author | Nagai, Yuji | en |
dc.contributor.author | Miyakawa, Naohisa | en |
dc.contributor.author | Mimura, Koki | en |
dc.contributor.author | Hirabayashi, Toshiyuki | en |
dc.contributor.author | Inoue, Ken-ichi | en |
dc.contributor.author | Suhara, Tetsuya | en |
dc.contributor.author | Takada, Masahiko | en |
dc.contributor.author | Higuchi, Makoto | en |
dc.contributor.author | Minamimoto, Takafumi | en |
dc.contributor.alternative | 小山, 佳 | ja |
dc.contributor.alternative | 堀, 由紀子 | ja |
dc.contributor.alternative | 永井, 裕司 | ja |
dc.contributor.alternative | 宮川, 尚久 | ja |
dc.contributor.alternative | 三村, 喬生 | ja |
dc.contributor.alternative | 平林, 敏行 | ja |
dc.contributor.alternative | 井上, 謙一 | ja |
dc.contributor.alternative | 須原, 哲也 | ja |
dc.contributor.alternative | 高田, 昌彦 | ja |
dc.contributor.alternative | 樋口, 真人 | ja |
dc.contributor.alternative | 南本, 敬史 | ja |
dc.date.accessioned | 2021-06-28T05:00:41Z | - |
dc.date.available | 2021-06-28T05:00:41Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.uri | http://hdl.handle.net/2433/263918 | - |
dc.description | 「何を買うんだっけ」と「どれにしよう」を処理する2つの脳回路を明らかに --霊長類の生体脳で神経経路を可視化・操作する技術で解明、高次脳機能の理解へ大きく前進--. 京都大学プレスリリース. 2021-06-24. | ja |
dc.description.abstract | The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the distinctive roles of these prefronto-subcortical pathways remain elusive. Combining in vivo neuronal projection mapping with chemogenetic synaptic silencing, we reversibly dissected key pathways from dorsolateral part of the PFC (dlPFC) to the dorsal caudate (dCD) and lateral mediodorsal thalamus (MDl) individually in single monkeys. We found that silencing the bilateral dlPFC-MDl projections, but not the dlPFC-dCD projections, impaired performance in a spatial working memory task. Conversely, silencing the unilateral dlPFC-dCD projection, but not the unilateral dlPFC-MDl projection, altered preference in a decision-making task. These results revealed dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates. | en |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | en |
dc.rights | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. | en |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.title | Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science Advances | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 26 | - |
dc.relation.doi | 10.1126/sciadv.abg4246 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | eabg4246 | - |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Systems Neuroscience Section, Primate Research Institute, Kyoto University; PRESTO, Japan Science and Technology Agency | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Systems Neuroscience Section, Primate Research Institute, Kyoto University | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.address | Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology | en |
dc.identifier.pmid | 34162548 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-06-24 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18K15353 | - |
datacite.awardNumber | 21K07268 | - |
datacite.awardNumber | 17H02219 | - |
datacite.awardNumber | 19H05467 | - |
datacite.awardNumber | 15H05917 | - |
datacite.awardNumber | 18H04037 | - |
datacite.awardNumber | 18H05018 | - |
datacite.awardNumber | 19K07811 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15353/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07268/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H02219/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H05467/ | - |
dc.identifier.eissn | 2375-2548 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 化学遺伝学による、柔軟な行動を実現するための霊長類神経経路機能の解明 | ja |
jpcoar.awardTitle | 点から線へ―化学遺伝学による霊長類前頭葉-皮質下回路の機能的理解 | ja |
jpcoar.awardTitle | 化学遺伝学とマルチモーダル計測による霊長類の柔軟な記憶想起ネットワークの解明 | ja |
jpcoar.awardTitle | 発達障害に関わる神経生物学的機構の霊長類的基盤の解明 | ja |
jpcoar.awardTitle | 質感認知に伴う情動惹起の神経機構 | ja |
jpcoar.awardTitle | ドーパミン・セロトニンによる意欲制御の脳内機構 | ja |
jpcoar.awardTitle | 偏桃体からのフィードバックが腹側視覚野の質感表現に及ぼす影響 | ja |
jpcoar.awardTitle | 扁桃体神経活動が霊長類の顔認知および顔認知神経回路に及ぼす影響 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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