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ファイル | 記述 | サイズ | フォーマット | |
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eLife.69340.pdf | 893.03 kB | Adobe PDF | 見る/開く |
タイトル: | Revisiting the guidelines for ending isolation for COVID-19 patients |
著者: | Jeong, Yong Dam Ejima, Keisuke Kim, Kwang Su Iwanami, Shoya Bento, Ana I Fujita, Yasuhisa Jung, Il Hyo Aihara, Kazuyuki Watashi, Koichi Miyazaki, Taiga Wakita, Takaji Iwami, Shingo Ajelli, Marco |
著者名の別形: | 江島, 啓介 岩波, 翔也 藤田, 泰久 合原, 一幸 渡士, 幸一 宮崎, 泰可 脇田, 隆字 岩見, 真吾 |
キーワード: | Research Article Microbiology and Infectious Disease COVID-19 mathematical model SARS-CoV-2 personalized medicine isolation |
発行日: | 2021 |
出版者: | eLife Sciences Publications, Ltd |
誌名: | eLife |
巻: | 10 |
論文番号: | e69340 |
抄録: | Since the start of the COVID-19 pandemic, two mainstream guidelines for defining when to end the isolation of SARS-CoV-2-infected individuals have been in use: the one-size-fits-all approach (i.e. patients are isolated for a fixed number of days) and the personalized approach (i.e. based on repeated testing of isolated patients). We use a mathematical framework to model within-host viral dynamics and test different criteria for ending isolation. By considering a fixed time of 10 days since symptom onset as the criterion for ending isolation, we estimated that the risk of releasing an individual who is still infectious is low (0–6.6%). However, this policy entails lengthy unnecessary isolations (4.8–8.3 days). In contrast, by using a personalized strategy, similar low risks can be reached with shorter prolonged isolations. The obtained findings provide a scientific rationale for policies on ending the isolation of SARS-CoV-2-infected individuals. |
記述: | 新型コロナウイルス感染者隔離を終了するのはいつが良い?. 京都大学プレスリリース. 2021-07-27. Reducing COVID-19 isolation times. 京都大学プレスリリース. 2021-07-27. |
著作権等: | © 2021, Jeong et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
URI: | http://hdl.handle.net/2433/264605 |
DOI(出版社版): | 10.7554/eLife.69340 |
PubMed ID: | 34311842 |
関連リンク: | https://ashbi.kyoto-u.ac.jp/ja/news/20210727_research-result_iwami/ https://ashbi.kyoto-u.ac.jp/news/20210727_research-result_iwami/ |
出現コレクション: | 学術雑誌掲載論文等 |
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