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タイトル: | 光力学診断補助下経尿道的膀胱腫瘍切除術(PDD-TURBT)の初期経験 |
その他のタイトル: | Initial Experience of Photodynamic Diagnosis-Assisted Transurethral Resection of Bladder Tumor (PDD-TURBT) |
著者: | 杉野, 友亮 西川, 晃平 加藤, 桃子 佐々木, 豪 加藤, 学 舛井, 覚 吉尾, 裕子 神田, 英輝 杉村, 芳樹 井上, 貴博 |
著者名の別形: | SUGINO, Yusuke NISHIKAWA, Kouhei KATO, Momoko SASAKI, Takeshi KATO, Manabu MASUI, Satoru YOSHIO, Yuko KANDA, Hideki SUGIMURA, Yoshiki INOUE, Takahiro |
キーワード: | Bladder cancer NMIBC TURBT PDD 5-ALA |
発行日: | 31-Jul-2021 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 67 |
号: | 7 |
開始ページ: | 303 |
終了ページ: | 308 |
抄録: | Photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) is expected to be useful in preventing oversight of non-muscle-invasive bladder cancer (NMIBC) and in reducing the intravesical recurrence rate after transurethral resection of bladder tumor (TURBT). We report our initial experience with28 cases of PDD-assisted TURBT (122 samples) performed at our hospital from February 2018 to April 2019. The median age of the patients was 74.5 years, and 18 of the 28 were primary cases. Each patient underwent TURBT with oral administration of 5-ALA 20 mg/kg 3 hours before endoscopic examination. The sensitivity was 89.8% when both white light and blue light were used, which was superior to the sensitivity of 67.8% when using only white light (p<0.01, McNemar’s test). Among the first several cases, we experienced high false positivity, which suggested that some experience may be required to discriminate tumors from inflammatory lesions. In fact, the specificity and the positive likelihood ratio improved with experience. No grade 2 or higher adverse events were observed among our cases. The median follow-up period was 738 days, and 9 of 28 patients (32. 1%) had recurrence within the follow-up period. In conclusion, our initial experience with PDD-assisted TURBT demonstrated its excellent diagnostic sensitivity and safety, as previously reported. |
著作権等: | 許諾条件により本文は2022-08-01に公開 |
DOI: | 10.14989/ActaUrolJap_67_7_303 |
URI: | http://hdl.handle.net/2433/264733 |
PubMed ID: | 34353010 |
出現コレクション: | Vol.67 No.7 |
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