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fragi.2021.719342.pdf | 3.59 MB | Adobe PDF | 見る/開く |
タイトル: | Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8⁺ T Cells in Unexposed Individuals |
著者: | Jo, Norihide https://orcid.org/0000-0002-9661-4546 (unconfirmed) Zhang, Rui Ueno, Hideki Yamamoto, Takuya https://orcid.org/0000-0002-0022-3947 (unconfirmed) Weiskopf, Daniela Nagao, Miki https://orcid.org/0000-0002-8886-6145 (unconfirmed) Yamanaka, Shinya Hamazaki, Yoko |
著者名の別形: | 城, 憲秀 上野, 英樹 山本, 拓也 長尾, 美紀 山中, 伸弥 濵﨑, 洋子 |
キーワード: | SARS-CoV-2 COVID-19 T-cell immunity cross-reactive T cells senescent T cells cytomegalovirus T cell aging |
発行日: | 2021 |
出版者: | Frontiers Media SA |
誌名: | Frontiers in Aging |
巻: | 2 |
論文番号: | 719342 |
抄録: | Age is a major risk factor for COVID-19 severity, and T cells play a central role in anti-SARS-CoV-2 immunity. Because SARS-CoV-2-cross-reactive T cells have been detected in unexposed individuals, we investigated the age-related differences in pre-existing SARS-CoV-2-reactive T cells. SARS-CoV-2-reactive CD4⁺ T cells from young and elderly individuals were mainly detected in the central memory fraction and exhibited similar functionalities and numbers. Naïve-phenotype SARS-CoV-2-reactive CD8⁺ T cell populations decreased markedly in the elderly, while those with terminally differentiated and senescent phenotypes increased. Furthermore, senescent SARS-CoV-2-reactive CD8⁺ T cell populations were higher in cytomegalovirus seropositive young individuals compared to seronegative ones. Our findings suggest that age-related differences in pre-existing SARS-CoV-2-reactive CD8+ T cells may explain the poor outcomes in elderly patients and that cytomegalovirus infection is a potential factor affecting CD8⁺ T cell immunity against SARS-CoV-2. Thus, this study provides insights for developing effective therapeutic and vaccination strategies for the elderly. |
記述: | 加齢やサイトメガロウイルス感染が新型コロナウイルス反応性キラーT細胞に与える影響. 京都大学プレスリリース. 2021-08-23. Severe COVID-19 symptoms in the elderly are consistent with a weaker immune system. 京都大学プレスリリース. 2021-08-23. |
著作権等: | © 2021 Jo, Zhang, Ueno, Yamamoto, Weiskopf, Nagao, Yamanaka and Hamazaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). |
URI: | http://hdl.handle.net/2433/265073 |
DOI(出版社版): | 10.3389/fragi.2021.719342 |
PubMed ID: | 35822004 |
関連リンク: | https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/210823-150000.html https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/210823-150000.html |
出現コレクション: | 学術雑誌掲載論文等 |
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