ダウンロード数: 94
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| jiab368.pdf | 1.84 MB | Adobe PDF | 見る/開く |
| タイトル: | SARS-CoV-2 B.1.617 mutations L452 and E484Q are not synergistic for antibody evasion |
| 著者: | Ferreira, Isabella Kemp, Steven Datir, Rawlings Saito, Akatsuki Meng, Bo Rakshit, Partha Takaori-Kondo, Akifumi Kosugi, Yusuke Uriu, Keiya Kimura, Izumi Shirakawa, Kotaro    https://orcid.org/0000-0002-7469-1276 (unconfirmed)Abdullahi, Adam The CITIID-NIHR BioResource COVID-19 Collaboration, The Indian SARS-CoV-2 Genomics Consortium (INSACOG) Agarwal, Anurag Ozono, Seiya Tokunaga, Kenzo Genotype to Phenotype Japan (G2P-Japan) Consortium Sato, Kei Gupta, Ravindra K. |
| 著者名の別形: | 齊藤, 暁 高折, 晃史 小杉, 優介 瓜生, 慧也 木村, 出海 白川, 康太郎 徳永, 研三 佐藤, 佳 |
| キーワード: | antibody escape B.1.617 COVID-19 evasion fitness Indian variant infectivity neutralizing antibodies resistance SARS-CoV-2 spike mutation mutation vaccines antibodies pathogenicity neutralizing antibodies sars-cov-2 covid-19 covid-19 vaccines |
| 発行日: | Sep-2021 |
| 出版者: | Oxford University Press (OUP) |
| 誌名: | The Journal of Infectious Diseases |
| 巻: | 224 |
| 号: | 6 |
| 開始ページ: | 989 |
| 終了ページ: | 994 |
| 抄録: | The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that two key mutations seen in the receptor binding domain L452R and E484Q would have additive effects on evasion of neutralising antibodies. We report that spike bearing L452R and E484Q confers modestly reduced sensitivity to BNT162b2 mRNA vaccine-elicited antibodies following either first or second dose. The effect is similar in magnitude to the loss of sensitivity conferred by L452R or E484Q alone. These data demonstrate reduced sensitivity to vaccine elicited neutralising antibodies by L452R and E484Q but lack of synergistic loss of sensitivity. |
| 記述: | SARS-CoV-2 B.1.617系統（俗称「インド株」）のL452R変異とE484Q変異は 中和抗体感受性の低下において、相加的な抵抗性を示さない. 京都大学プレスリリース. 2021-08-24. |
| 著作権等: | © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| URI: | http://hdl.handle.net/2433/265297 |
| DOI(出版社版): | 10.1093/infdis/jiab368 |
| PubMed ID: | 34260717 |
| 関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2021-08-24 |
| 出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス
