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j.actaastro.2020.07.002.pdf | 1.18 MB | Adobe PDF | 見る/開く |
タイトル: | Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice |
著者: | Egawa, Tatsuro ![]() ![]() ![]() Kido, Kohei Yokokawa, Takumi ![]() ![]() ![]() Fujibayashi, Mami Goto, Katsumasa Hayashi, Tatsuya ![]() ![]() ![]() |
著者名の別形: | 江川, 達郎 木戸, 康平 横川, 拓海 林, 達也 |
キーワード: | RAGE Interleukin-1 Interleukin-6 Methylglyoxal Tumor necrosis factor-α Ubiquitin-proteasome system |
発行日: | Nov-2020 |
出版者: | Elsevier Ltd |
誌名: | Acta Astronautica |
巻: | 176 |
開始ページ: | 332 |
終了ページ: | 340 |
抄録: | The accumulation of advanced glycation end-products (AGEs) may be involved in the mechanism of skeletal muscle atrophy. However, the involvement of the receptor for AGEs (RAGE) axis in microgravity-induced skeletal muscle atrophy has not been investigated. Therefore, the purpose of the present study was to investigate the effect of RAGE inhibition on microgravity-induced skeletal muscle atrophy and the related molecular responses. Male C57BL/6NCr mice subjected to a 1-week hindlimb suspension lead to muscle atrophy in soleus and plantaris but not extensor digitorum longus muscle, accompanied by increases in RAGE expression. However, treatment with a RAGE antagonist (FPS-ZM1, intraperitoneal, 1 mg/kg/day) during hindlimb suspension ameliorated the atrophic responses in soleus muscle. Further, muscle mass inversely correlated with the accumulation of AGEs (methylglyoxal-modified proteins and Nε-(carboxymethyl) lysine-modified proteins) in soleus muscle. The expression of proinflammatory cytokines, tumor necrosis factor-α, interleukin-1β, and interleukin-6 in soleus muscle was enhanced in response to hindlimb suspension, but these changes were attenuated by FPS-ZM1 treatment. Protein ubiquitination and ubiquitin E3 ligase (muscle RING finger 1) expression in soleus muscle were elevated following hindlimb suspension, and these increments were suppressed by FPS-ZM1 treatment. Our findings indicate that the AGE-RAGE axis is upregulated in unloaded atrophied skeletal muscle, and that RAGE inhibition ameliorates microgravity-induced skeletal muscle atrophy by reducing proinflammatory cytokine expression and ubiquitin-proteasome system activation. |
著作権等: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 01 November 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving' This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/266463 |
DOI(出版社版): | 10.1016/j.actaastro.2020.07.002 |
出現コレクション: | 学術雑誌掲載論文等 |
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