|Title:||Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core|
Tsukano, Chihiro https://orcid.org/0000-0002-9361-0857 (unconfirmed)
Nanjo, Takeshi https://orcid.org/0000-0002-5679-6701 (unconfirmed)
Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed)
|Author's alias:||黒瀬, 朋浩|
|Publisher:||American Chemical Society (ACS)|
|Journal title:||Organic Letters|
|Abstract:||This report describes the total synthesis of the complex, oxygenated tetracyclic alkaloid, lyconesidine B. The key synthetic challenge involves diastereoselective generation of a decahydroquinoline ring with a quaternary carbon at the angular position via domino cyclopropanation, ring-opening, and reduction. Another crucial step is the domino ene-yne metathesis involving a quaternary ammonium ion, leading to the construction of a decahydroazaazulen framework.|
|Rights:||This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.0c03816.|
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|Appears in Collections:||Journal Articles|
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