このアイテムのアクセス数: 140
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.bmcl.2021.128103.pdf | 1.61 MB | Adobe PDF | 見る/開く |
| タイトル: | Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine |
| 著者: | Kuroki, Kakeru Sakai, Takayuki Masuda, Toshihiro Kawano, Kenichi    https://orcid.org/0000-0003-1927-2922 (unconfirmed)Futaki, Shiroh |
| 著者名の別形: | 黒木, 翔 阪井, 貴之 益田, 俊博 河野, 健一 二木, 史朗 |
| キーワード: | Curvature-inducing peptide Octaarginine Cell membrane translocation Pyrenebutyric acid Lipid packing loosening |
| 発行日: | Jul-2021 |
| 出版者: | Elsevier BV |
| 誌名: | Bioorganic and Medicinal Chemistry Letters |
| 巻: | 43 |
| 論文番号: | 128103 |
| 抄録: | EpN18 is a curvature-inducing peptide, which loosens lipid packing upon interaction with the cell membrane, and facilitates cell-membrane penetration by arginine-rich cell-penetrating peptides, including octaarginine (R8). In the present study, we conjugated the N-terminal of EpN18 with a pyrenebutyryl (pBu) moiety, which acts as an anchoring unit that increases membrane interactions. Enhanced lipid-packing loosening and cytosolic translocation of R8 were observed by the pBu anchoring of EpN18. |
| 著作権等: | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. The full-text file will be made open to the public on 1 July 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/267223 |
| DOI(出版社版): | 10.1016/j.bmcl.2021.128103 |
| PubMed ID: | 33984474 |
| 出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス
