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j.celrep.2021.110218.pdf | 3.08 MB | Adobe PDF | 見る/開く |
タイトル: | The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance |
著者: | Kimura, Izumi Kosugi, Yusuke Wu, Jiaqi Zahradnik, Jiri Yamasoba, Daichi Butlertanaka, Erika P. Tanaka, Yuri L. Uriu, Keiya Liu, Yafei Morizako, Nanami Shirakawa, Kotaro https://orcid.org/0000-0002-7469-1276 (unconfirmed) Kazuma, Yasuhiro Nomura, Ryosuke Horisawa, Yoshihito Tokunaga, Kenzo Ueno, Takamasa Takaori-Kondo, Akifumi Schreiber, Gideon Arase, Hisashi The Genotype to Phenotype Japan (G2P-Japan) Consortium Motozono, Chihiro Saito, Akatsuki Nakagawa, So Sato, Kei |
著者名の別形: | 木村, 出海 小杉, 優介 呉, 佳齊 山岨, 大智 バトラー田中, 英里佳 田中, 友理 瓜生, 慧也 森迫, 奈菜実 白川, 康太郎 数馬, 安浩 野村, 亮介 堀澤, 欣史 徳永, 研三 上野, 貴將 高折, 晃史 荒瀬, 尚 本園, 千尋 齊藤, 暁 中川, 草 佐藤, 佳 |
キーワード: | SARS-CoV-2 COVID-19 spike protein C.37 Lambda |
発行日: | Jan-2022 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 38 |
号: | 2 |
論文番号: | 110218 |
抄録: | SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unknown. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino-acid deletion in the N-terminal domain of the Lambda spike protein, is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection. Although this mutation generates a nascent N-linked glycosylation site, the additional N-linked glycan is dispensable for the virological property conferred by this mutation. Since the Lambda variant has dominantly spread according to the increasing frequency of the isolates harboring the RSYLTPGD246-253N mutation, our data suggest that the RSYLTPGD246-253N mutation is closely associated with the substantial spread of the Lambda variant in South America. |
記述: | SARS-CoV-2ラムダ株のウイルス学的・免疫学的性状の解明. 京都大学プレスリリース. 2021-12-23. |
著作権等: | © 2021 The Author(s). This is an open access article under the Creative Commons Attribution 4.0 International license. |
URI: | http://hdl.handle.net/2433/267436 |
DOI(出版社版): | 10.1016/j.celrep.2021.110218 |
PubMed ID: | 34968415 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2021-12-23-1 |
出現コレクション: | 学術雑誌掲載論文等 |
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