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ファイル | 記述 | サイズ | フォーマット | |
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j.copbio.2021.06.023.pdf | 1.4 MB | Adobe PDF | 見る/開く |
タイトル: | Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics |
著者: | Ojima, Miriam N Yoshida, Keisuke Sakanaka, Mikiyasu Jiang, Lin Odamaki, Toshitaka Katayama, Takane https://orcid.org/0000-0003-4009-7874 (unconfirmed) |
著者名の別形: | 尾島, 望美 阪中, 幹祥 小田巻, 俊孝 片山, 高嶺 |
発行日: | Feb-2022 |
出版者: | Elsevier BV |
誌名: | Current Opinion in Biotechnology |
巻: | 73 |
開始ページ: | 108 |
終了ページ: | 120 |
抄録: | Bifidobacteria are widely used as a probiotic for their health-promoting effects. To promote their growth, bifidogenic prebiotics, including human milk oligosaccharides (HMOs), have been added to supplements and infant formula. However, the efficacy of both probiotic and prebiotic interventions is often debated, as clinical responses vary significantly by case. Here, we review clinical studies that aimed to proliferate human-residential Bifidobacterium (HRB) strains in the gut, and we highlight the difference between responders and non-responders to such interventions through an ecological, niche-based perspective and an examination of the prevalence of genes responsible for prebiotic assimilation in HRB genomes. We discuss the criteria necessary to better evaluate the efficacy of probiotic and prebiotic interventions and the recent therapeutic potential shown by synbiotics. |
著作権等: | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. The full-text file will be made open to the public on 1 February 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/267481 |
DOI(出版社版): | 10.1016/j.copbio.2021.06.023 |
PubMed ID: | 34375845 |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス