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タイトル: | Long-term air pollution exposure and serum lipids and blood sugar: A longitudinal cohort study from the electricity generating authority of Thailand study |
著者: | Paoin, Kanawat Ueda, Kayo Vathesatogkit, Prin Ingviya, Thammasin Buya, Suhaimee Phosri, Arthit Seposo, Xerxes Tesoro Thongmung, Nisakron Yingchoncharoen, Teerapat Honda, Akiko https://orcid.org/0000-0002-7358-4372 (unconfirmed) Takano, Hirohisa https://orcid.org/0000-0002-3748-6206 (unconfirmed) Sritara, Piyamitr |
著者名の別形: | 上田, 佳代 本田, 晶子 高野, 裕久 |
キーワード: | Long-term exposure Air pollution Longitudinal study Serum lipids Blood sugar |
発行日: | 15-Aug-2021 |
出版者: | Elsevier BV |
誌名: | Atmospheric Environment |
巻: | 259 |
論文番号: | 118515 |
抄録: | Only a few studies have investigated the association between long-term exposure to air pollution and alterations of serum lipids and blood sugar level in developing countries. The present longitudinal study examined associations between long-term air pollution exposure and serum lipids [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] and fasting glucose (FG) in workers of the Electricity Generating Authority of Thailand (EGAT) in the Bangkok metropolitan region (BMR) of Thailand. We performed secondary analyses using the data obtained from 1, 839 participants (mean age, 58.3 years as of 2002) of the EGAT1 cohort study (2002–2012). The average concentration of each air pollutants (PM₁₀, O₃, NO₂, SO₂, and CO) at the sub-district level in BMR from 2002 to 2012 were estimated using the ordinary kriging method. Exposure periods were averaged to 3 months prior to laboratory testing. Linear mixed effects models were used to estimate associations between air pollution and serum lipids and blood sugar. After controlling for potential confounders, an interquartile range increment of PM₁₀, SO₂, and CO was associated with elevated LDL-C [6.6% (95%CI: 4.3, 9.0), 11.1% (7.2, 15.2), and 1.9% (1.1, 2.7), respectively] and FG [2.8% (1.5, 4.2), 6.8% (4.5, 9.1), and 1.1% (0.6, 1.5), respectively]. In addition, PM10, SO2, and CO were inversely associated with HDL-C [-1.8% (−3.7, 0.1), −3.3% (−6.2, −0.3), and −1.1 (−1.7, −0.5), respectively]. O₃ was negatively associated with TC, LDL-C, TG, and FG. These findings suggest inhalation of air pollutants may increase the risk of impaired metabolism of glucose and lipids. |
著作権等: | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 license. The full-text file will be made open to the public on 15 August 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving' This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/268290 |
DOI(出版社版): | 10.1016/j.atmosenv.2021.118515 |
出現コレクション: | 学術雑誌掲載論文等 |
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