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タイトル: | Nonbiomimetic total synthesis of indole alkaloids using alkyne-based strategies |
著者: | Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed) Inuki, Shinsuke https://orcid.org/0000-0002-7525-1280 (unconfirmed) |
著者名の別形: | 大野, 浩章 井貫, 晋輔 |
発行日: | 28-Apr-2021 |
出版者: | Royal Society of Chemistry (RSC) |
誌名: | Organic & Biomolecular Chemistry |
巻: | 19 |
号: | 16 |
開始ページ: | 3551 |
終了ページ: | 3568 |
抄録: | Biomimetic natural product synthesis is generally straightforward and efficient because of its established feasibility in nature and utility in comprehensive synthesis, and the cost-effectiveness of naturally derived starting materials. On the other hand, nonbiomimetic strategies can be an important option in natural product synthesis since (1) nonbiomimetic synthesis offers more flexibility and can demonstrate the originality of chemists, and (2) the structures of derivatives accessible by nonbiomimetic synthesis can be considerably different from those that are synthesised in nature. This review summarises nonbiomimetic total syntheses of indole alkaloids using alkyne chemistry for constructing core structures, including ergot alkaloids, monoterpene indole alkaloids (mainly corynanthe, aspidosperma, strychnos, and akuammiline), and pyrroloindole and related alkaloids. To clarify the differences between alkyne-based strategies and biosynthesis, the alkynes in nature and the biosyntheses of indole alkaloids are also outlined. |
著作権等: | This is an accepted manuscript of this article, which has been published in final form at https://doi.org/10.1039/d0ob02577a. The full-text file will be made open to the public on 24 Mar 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/268304 |
DOI(出版社版): | 10.1039/d0ob02577a |
PubMed ID: | 33908430 |
出現コレクション: | 学術雑誌掲載論文等 |
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