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タイトル: | Post-transcriptional regulation of immunological responses by Regnase-1-related RNases |
著者: | Uehata, Takuya ![]() ![]() Takeuchi, Osamu ![]() ![]() ![]() |
著者名の別形: | 植畑, 拓也 竹内, 理 |
キーワード: | antiviral host defense inflammation mRNA decay RNA-binding proteins cytokine gene expression transcription, genetic inflammation immune response ulcerative colitis antiviral agents endoribonucleases immunity rna, messenger rna-binding proteins untranslated regions idiopathic pulmonary fibrosis host defense inflammatory disorders cytokinesis catabolism |
発行日: | Dec-2021 |
出版者: | Oxford University Press (OUP) |
誌名: | International Immunology |
巻: | 33 |
号: | 12 |
開始ページ: | 859 |
終了ページ: | 865 |
抄録: | Regulation of messenger RNA (mRNA) decay plays a crucial role in the control of gene expression. Canonical mRNA decay pathways are initiated by deadenylation and decapping, and are followed by exonucleolytic degradation. However, recent studies revealed that endoribonucleolytic cleavage also mediates mRNA decay, and both exoribonucleolytic and endoribonucleolytic decay pathways are important for the regulation of immune responses. Regnase-1 functions as an endoribonuclease to control immunity by damping mRNAs. Particularly, Regnase-1 controls cytokines and other inflammatory mediators by recognizing their mRNAs via stem-loop structures present in the 3' untranslated regions. Regnase-1 was found to be critical for human inflammatory diseases such as ulcerative colitis and idiopathic pulmonary fibrosis. Furthermore, a set of Regnase-1-related RNases contribute to immune regulation as well as antiviral host defense. In this review, we provide an overview of recent findings as to immune-related RNA-binding proteins (RBPs) with an emphasis on stem-loop-mediated mRNA decay via Regnase-1 and related RNases and discuss how the function of these RBPs is regulated and contributes to inflammatory disorders. |
著作権等: | This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record [Takuya Uehata, Osamu Takeuchi, Post-transcriptional regulation of immunological responses by Regnase-1-related RNases, International Immunology, Volume 33, Issue 12, December 2021, Pages 859–865] is available online at: https://doi.org/10.1093/intimm/dxab048. The full-text file will be made open to the public on 28 July 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/268775 |
DOI(出版社版): | 10.1093/intimm/dxab048 |
PubMed ID: | 34320195 |
出現コレクション: | 学術雑誌掲載論文等 |

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