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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| acs.bioconjchem.1c00302.pdf | 2.24 MB | Adobe PDF | 見る/開く |
| タイトル: | Photo-Controllable Phase Transition of Arylazopyrazole-Conjugated Oligonucleotides |
| 著者: | Hidaka, Takuya Wee, Wen Ann Yum, Ji Hye Sugiyama, Hiroshi    https://orcid.org/0000-0001-8923-5946 (unconfirmed)Park, Soyoung |
| 著者名の別形: | 日髙, 拓也 黄, 文 廉, 知恵 杉山, 弘 朴, 昭映 |
| キーワード: | Electromagnetic radiation Genetics Biopolymers Phase transitions Irradiation |
| 発行日: | Oct-2021 |
| 出版者: | American Chemical Society (ACS) |
| 誌名: | Bioconjugate Chemistry |
| 巻: | 32 |
| 号: | 10 |
| 開始ページ: | 2129 |
| 終了ページ: | 2133 |
| 抄録: | Phase transition is a promising aspect of DNA as biopolymers. Anionic DNA oligonucleotides easily form complexes with cationic polypeptides such as polylysine, and duplex formation significantly influences their complexation and resulting microcompartments. In this study, phase transition of microcompartments containing DNA and polylysine was systematically induced by modulating duplex formation of arylazopyrazole-conjugated oligonucleotides with light. We demonstrated that UV irradiation destabilized DNA duplex and generated isotropic coacervates, while duplex stabilization by visible light irradiation caused the formation of liquid crystalline coacervates. This photocontrol of phase transition was highly repeatable, and similar changes were observed even after ten cycles of light irradiation. Our approach would provide a robust control layer to the development of tailor-made microcompartments. |
| 著作権等: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, Copyright © 2021 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.bioconjchem.1c00302. The full-text file will be made open to the public on 9 September 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/268794 |
| DOI(出版社版): | 10.1021/acs.bioconjchem.1c00302 |
| PubMed ID: | 34498851 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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