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dc.contributor.authorTsutsui, Takeyoshien
dc.contributor.authorArakawa, Yoshikien
dc.contributor.authorMakino, Yasuhideen
dc.contributor.authorKataoka, Hiroharuen
dc.contributor.authorMineharu, Yoheien
dc.contributor.authorNaito, Kentaroen
dc.contributor.authorMinamiguchi, Sachikoen
dc.contributor.authorHirose, Takanorien
dc.contributor.authorNobusawa, Sumihitoen
dc.contributor.authorNakano, Yoshikoen
dc.contributor.authorIchimura, Koichien
dc.contributor.authorHaga, Hironorien
dc.contributor.authorMiyamoto, Susumuen
dc.contributor.alternative筒井, 偉宝ja
dc.contributor.alternative荒川, 芳輝ja
dc.contributor.alternative牧野, 恭秀ja
dc.contributor.alternative片岡, 大治ja
dc.contributor.alternative峰晴, 陽平ja
dc.contributor.alternative南口, 早智子ja
dc.contributor.alternative羽賀, 博典ja
dc.contributor.alternative宮本, 享ja
dc.date.accessioned2022-03-14T01:05:51Z-
dc.date.available2022-03-14T01:05:51Z-
dc.date.issued2021-10-
dc.identifier.urihttp://hdl.handle.net/2433/268873-
dc.description.abstractThe most recurrent fusion of central nervous system high-grade neuroepithelial tumor with MN1 alteration (HGNET-MN1) is MN1 rearrangement. Here, we report the case of a 36-year-old man with spinal cord astroblastoma showing Ewing Sarcoma breakpoint region 1/EWS RNA-binding protein 1 (EWSR1)-BEN domain-containing 2 (BEND2) fusion. The patient presented with back pain, gait disturbance and dysesthesia in the lower extremities and trunk. Magnetic resonance imaging showed an intramedullary tumor at the T3-5 level, displaying homogeneous gadolinium enhancement. Partial tumor removal was performed with laminectomy. Histological examinations demonstrated solid growth of epithelioid tumor cells showing high cellularity, a pseudopapillary structure, intervening hyalinized fibrous stroma, and some mitoses. Astroblastoma was diagnosed, classified as HGNET-MN1 by the German Cancer Research Center methylation classifier. MN1 alteration was not detected by fluorescence in situ hybridization (FISH), but EWSR1-BEND2 fusion was detected by FISH and RNA sequencing. Previously, a child with EWSR1-BEND2 fusion-positive spinal astroblastoma classified as HGNET-MN1 was reported. In conjunction with that, the present case provides evidence that EWSR1-BEND2 fusion is identified in the entity of HGNET-MN1. Taken together, the BEND2 alteration rather than MN1 may determine the biology of a subset of the central nervous system HGNET-MN1 subclass.en
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10014-021-00412-3.en
dc.rightsThe full-text file will be made open to the public on 27 July 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。en
dc.subjectCancer Researchen
dc.subjectClinical Neurologyen
dc.subjectOncologyen
dc.subjectGeneral Medicineen
dc.titleSpinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case reporten
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleBrain Tumor Pathologyen
dc.identifier.volume38-
dc.identifier.issue4-
dc.identifier.spage283-
dc.identifier.epage289-
dc.relation.doi10.1007/s10014-021-00412-3-
dc.textversionauthor-
dc.identifier.pmid34313881-
dcterms.accessRightsopen access-
datacite.date.available2022-07-27-
datacite.awardNumber19K09505-
datacite.awardNumber19K22685-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09505/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22685/-
dc.identifier.pissn1433-7398-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitleリプログラミング技術による非定型奇形腫様ラブドイド腫瘍のエピゲノム解析と治療開発ja
jpcoar.awardTitleグリオーマのステムネス維持転写ネットワークを標的とした核酸類似化合物開発の挑戦ja
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