このアイテムのアクセス数: 116
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| 1440-1681.13621.pdf | 1.47 MB | Adobe PDF | 見る/開く |
| タイトル: | Salt loading with unilateral nephrectomy accelerate decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease |
| 著者: | Shinozaki, Yuichi Katayama, Yuko Yamaguchi, Fuminari Suzuki, Tomohisa Watanabe, Kana Uno, Kinuko   Tsutsui, Takahiro Sugimoto, Miki Shinohara, Masami Miyajima, Katsuhiro Ohta, Takeshi |
| 著者名の別形: | 篠崎, 雄一 筒井, 誉大 杉本, 実紀 太田, 毅 |
| キーワード: | GFR decline salt loading SDT fatty rat unilateral nephrectomy |
| 発行日: | Apr-2022 |
| 出版者: | Wiley |
| 誌名: | Clinical and Experimental Pharmacology and Physiology |
| 巻: | 49 |
| 号: | 4 |
| 開始ページ: | 492 |
| 終了ページ: | 500 |
| 抄録: | For the evaluation of novel therapeutic agents for diabetic kidney disease (DKD), it is desirable to examine their efficacy in animal models by using the glomerular filtration rate (GFR) as an index. For this purpose, animal models that demonstrate a short-term GFR decline because of disease progression are required. Therefore, we aimed to develop such an animal model of DKD by using obese type 2 diabetic spontaneously diabetic Torii (SDT) fatty rats treated with salt loading by drinking water containing sodium chloride with or without unilateral nephrectomy. As a result, we have found that 0.3% salt loading with unilateral nephrectomy or 0.8% salt loading alone caused a rapid GFR decline, hypertension and rapid development of tubulointerstitial fibrosis. Moreover, the addition of losartan to a mixed diet suppressed the GFR decline in SDT fatty rats treated with 0.3% salt loading with unilateral nephrectomy. These results suggest that the model of SDT fatty rats treated with 0.3% salt loading and unilateral nephrectomy could be used as a hypertensive DKD model for evaluating therapeutic agents based on suppression of GFR decline. |
| 著作権等: | This is the peer reviewed version of the following article: [Shinozaki, Y, Katayama, Y, Yamaguchi, F, et al. Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease. Clin Exp Pharmacol Physiol. 2022; 49: 492– 500.], which has been published in final form at https://doi.org/10.1111/1440-1681.13621. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. The full-text file will be made open to the public on 04 February 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/268906 |
| DOI(出版社版): | 10.1111/1440-1681.13621 |
| PubMed ID: | 35066915 |
| 出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。