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dc.contributor.authorKido, Aien
dc.contributor.authorMiyake, Masahiroen
dc.contributor.authorTamura, Hiroshien
dc.contributor.authorHiragi, Shusukeen
dc.contributor.authorKimura, Takeshien
dc.contributor.authorYoshida, Satomien
dc.contributor.authorTakeuchi, Masatoen
dc.contributor.authorOhtera, Shosukeen
dc.contributor.authorTakahashi, Ayakoen
dc.contributor.authorOoto, Sotaroen
dc.contributor.authorKawakami, Kojien
dc.contributor.authorKuroda, Tomohiroen
dc.contributor.authorTsujikawa, Akitakaen
dc.contributor.alternative木戸, 愛ja
dc.contributor.alternative三宅, 正裕ja
dc.contributor.alternative田村, 寛ja
dc.contributor.alternative平木, 秀輔ja
dc.contributor.alternative木村, 丈ja
dc.contributor.alternative吉田, 都美ja
dc.contributor.alternative竹内, 正人ja
dc.contributor.alternative大寺, 祥佑ja
dc.contributor.alternative高橋, 綾子ja
dc.contributor.alternative大音, 壮太郎ja
dc.contributor.alternative川上, 浩司ja
dc.contributor.alternative黒田, 知宏ja
dc.contributor.alternative辻川, 明孝ja
dc.date.accessioned2022-03-17T00:56:03Z-
dc.date.available2022-03-17T00:56:03Z-
dc.date.issued2022-06-
dc.identifier.urihttp://hdl.handle.net/2433/268925-
dc.description失明原因となる加齢黄斑変性の日本人の疫学と治療実態を明らかに --国の診療報酬請求データベースを用いた臨床研究--. 京都大学プレスリリース. 2022-03-04.ja
dc.description.abstract[Purpose] To elucidate the incidence and treatment pattern of active exudative age-related macular degeneration (AMD). [Design] A population-based cohort study conducted using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), a national claims database managed by the Japanese Ministry of Health, Labour, and Welfare (MHLW). [Participants] The entire Japanese population aged 40 years or older (76 million people). [Methods] With the permission of the MHLW, we accessed the complete NDB dataset and identified patients with newly diagnosed active exudative AMD between 2011 and 2018. The incidence of active exudative AMD was categorized by age and sex per year between 2011 and 2018; moreover, details regarding first-line therapy and number of anti-vascular endothelial growth factor (VEGF) injections per elapsed year since initial treatment were obtained and changes in treatment pattern were investigated. [Main Outcome Measures] Incidence rate of active exudative AMD. [Results] During the specified 8-year period, 246 064 incident cases of active exudative AMD were identified; 61.4% of these patients were men. The overall incidence rate was 40.66 per 100 000 person-years (95% confidence interval [CI], 40.49–40.82) in the general population aged 40 years or older, 53.22 (95% CI, 52.95–53.49) in men, and 29.78 (95% CI, 29.60–29.98) in women. Mean age of onset was lower in men than in women (72.51 ± 10.50 years vs. 73.90 ± 10.46 years). Among patients with newly diagnosed active exudative AMD, 92.9% received anti-VEGF injections for initial treatments, whereas 1.8% underwent combination therapy with photodynamic therapy. The number of anti-VEGF injections in the first year (0–12 months), second year (13–24 months), and third year (25–36 months) after the initial injection was 3.66 ± 2.30, 1.39 ± 2.20, and 1.23 ± 2.19, respectively. Patients who received fewer injections in the first year received fewer injections in subsequent years and vice versa. [Conclusions] This is a relatively large population-based study on the detailed epidemiology and actual treatment patterns of active exudative AMD in clinical practice. Our results can be a fundamental information source to ensure healthy eyes and promote well-being for all at all ages.en
dc.language.isoeng-
dc.publisherAmerican Academy of Ophthalmologyen
dc.publisherElsevier BVen
dc.rights© 2022 by the American Academy of Ophthalmologyen
dc.rightsThis is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. Published by Elsevier Inc.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectIncidence rateen
dc.subjectHealth insurance claims databaseen
dc.subjectEpidemiologyen
dc.subjectAge-related macular degenerationen
dc.titleIncidence and Real-world Clinical Practice of Exudative Age-related Macular Degeneration: A Nationwide Population-Based Cohort Studyen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleOphthalmology Scienceen
dc.identifier.volume2-
dc.identifier.issue2-
dc.relation.doi10.1016/j.xops.2022.100125-
dc.textversionpublisher-
dc.identifier.artnum100125-
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine; Department of Phamacoepidemiology, Graduate School of Medicine and Public Health, Kyoto Universityen
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicineen
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine; Center for Innovative Research and Education in Data Science, Institute for Liberal Arts and Sciences, Kyoto Universityen
dc.addressDivision of Medical Informatics and Administration Planning, Kyoto University Hospital; Kitano Hospital, Medical Research Institute, the Tazuke Kofukai Medical Research Instituteen
dc.addressDepartment of Phamacoepidemiology, Graduate School of Medicine and Public Health, Kyoto Universityen
dc.addressDepartment of Phamacoepidemiology, Graduate School of Medicine and Public Health, Kyoto Universityen
dc.addressDepartment of Phamacoepidemiology, Graduate School of Medicine and Public Health, Kyoto Universityen
dc.addressDivision of Medical Informatics and Administration Planning, Kyoto University Hospital; Center for Outcomes Research and Economic Evaluation for Health, The National Institute of Public Healthen
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicineen
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicineen
dc.addressDepartment of Phamacoepidemiology, Graduate School of Medicine and Public Health, Kyoto Universityen
dc.addressDivision of Medical Informatics and Administration Planning, Kyoto University Hospitalen
dc.addressDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicineen
dc.identifier.pmid36249688-
dc.relation.urlhttps://www.kyoto-u.ac.jp/ja/research-news/2022-03-04-0-
dcterms.accessRightsopen access-
datacite.awardNumber21K09740-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09740/-
dc.identifier.eissn2666-9145-
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitle全レセプトデータ(NDB)を用いた眼科難病・希少疾患・難治性疾患の疫学研究ja
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