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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41232-020-00150-7.pdf | 2.1 MB | Adobe PDF | 見る/開く |
| タイトル: | Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings |
| 著者: | Masuda, Kyoko Kawamoto, Hiroshi    https://orcid.org/0000-0002-7670-9900 (unconfirmed) |
| 著者名の別形: | 増田, 喬子 河本, 宏 |
| キーワード: | NK cells Missing-self recognition KIR-ligand mismatch Induced pluripotent stem cells (iPSCs) Homo-to-hetero transplantation |
| 発行日: | 2021 |
| 出版者: | Springer Nature BMC |
| 誌名: | Inflammation and Regeneration |
| 巻: | 41 |
| 論文番号: | 2 |
| 抄録: | In the regenerative medicine field, allogenic transplantation of regenerated tissues has been promoted because autologous transplantation setting is costly and time-consuming to prepare and therefore unsuitable for emergent treatment. To avoid a T cell-mediated immune rejection in the allogenic transplantation setting, induced pluripotent stem cells (iPSCs) derived from different HLA haplotype-homozygous (HLA-homo) donors have been prepared to be used as source of regenerated tissues. However, there still remain immunological issues, even when HLA-homo iPSCs are used. One issue is the immune response against minor histocompatibility antigens expressed on the regenerated tissues, and the other is the immune rejection mediated by NK cells. In this article, we introduce our research on NK cell reactivity against the regenerated tissues in the HLA homo-to-hetero transplantation setting. We further introduce several approaches taken by other groups that address the NK-mediated immune rejection issue. |
| 著作権等: | © The Author(s). 2020 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/274457 |
| DOI(出版社版): | 10.1186/s41232-020-00150-7 |
| PubMed ID: | 33407951 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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