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タイトル: Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells
著者: Ado, Genyir
Noda, Naotaka
Vu, Hue T.
Perron, Amelie  KAKEN_id
Mahapatra, Amarjyoti D.
Arista, Karla Pineda
Yoshimura, Hideaki
Packwood, Daniel M.
Ishidate, Fumiyoshi
Sato, Shin-ichi
Ozawa, Takeaki
Uesugi, Motonari  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8515-445X (unconfirmed)
著者名の別形: 野田, 尚孝
石館, 文善
佐藤, 慎一
上杉, 志成
発行日: 20-Apr-2022
出版者: Royal Society of Chemistry (RSC)
誌名: Chemical Science
巻: 13
号: 19
開始ページ: 5760
終了ページ: 5766
抄録: Phase-separated membraneless organelles or biomolecular condensates play diverse functions in cells, however recapturing their characteristics using small organic molecules has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small molecules led to the discovery of a simple organic molecule, named huezole, that forms liquid droplets to selectively sequester tubulin. Remarkably, this small molecule enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells. The present study demonstrates the feasibility of producing a synthetic condensate out of non-peptidic small molecules for exogenous control of cellular processes. The modular structure of huezole provides a framework for designing a class of organelle-emulating small molecules.
著作権等: © The Royal Society of Chemistry 2022
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
URI: http://hdl.handle.net/2433/274623
DOI(出版社版): 10.1039/d1sc07151c
PubMed ID: 35694339
出現コレクション:学術雑誌掲載論文等

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