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Title: Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance
Authors: Okuda, Satoru
Inoue, Yasuhiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1968-8883 (unconfirmed)
Eiraku, Mototsugu  kyouindb  KAKEN_id
Sasai, Yoshiki
Adachi, Taiji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5280-4156 (unconfirmed)
Author's alias: 井上, 康博
安達, 泰治
Keywords: Tissue morphogenesis
Multicellular dynamics
Three-dimensional vertex model
Reversible network reconnection model
Developmental biomechanics
Issue Date: 21-Jun-2013
Publisher: Elsevier BV
Journal title: Journal of Biomechanics
Volume: 46
Issue: 10
Start page: 1705
End page: 1713
Abstract: In general, a rapidly growing epithelial sheet during tissue morphogenesis shows a smooth and continuous curvature on both inner cavity (apical) and basement membrane (basal) sides. For instance, epithelia of the neural tube and optic vesicle in the early embryo maintain continuous curvatures in their local domains, even during their rapid growth. However, given that cell divisions, which substantially perturb the local force balance, frequently and successively occur in an uncoordinated manner, it is not self-evident to explain how the tissue keeps a continuous curvature at large. In the majority of developing embryonic epithelia with smooth surfaces, their curvatures are apically concave, because of the presence of strong tangential contractile force on the apical side. In this numerical study, we demonstrate that tangential contractile forces on the apical surface play a critical role in the maintenance of smooth curvatures in the epithelium and reduce irregular undulations caused by uncoordinated generation of local pushing force. Using a reversible network reconnection (RNR) model, which we previously developed to make numerical analyses highly reproducible even under rapid tissue-growth conditions, we performed simulations for morphodynamics to examine the effect of apical contractile forces on the continuity of curvatures. Interestingly, the presence of apical contractile forces suppressed irregular undulations not only on the apical side but also on the basal surface. These results indicate that cellular contractile forces on the apical surface control not only the shape at a single cell level but also at a tissue level as a result of emergent mechanical coordination.
Rights: © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 21 June 2014 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/274888
DOI(Published Version): 10.1016/j.jbiomech.2013.03.035
PubMed ID: 23676291
Appears in Collections:Journal Articles

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