ダウンロード数: 80
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.chembiol.2021.08.001.pdf | 4.65 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Malinee, Madhu | en |
dc.contributor.author | Namasivayam, Ganesh Pandian | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | ナマシヴァヤム, ガネシュ・パンディアン | ja |
dc.contributor.alternative | 杉山, 弘 | ja |
dc.date.accessioned | 2022-07-28T00:11:11Z | - |
dc.date.available | 2022-07-28T00:11:11Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.uri | http://hdl.handle.net/2433/275627 | - |
dc.description | PD-1阻害剤によるがん免疫治療法の効果を高めるミトコンドリア活性化剤. 京都大学プレスリリース. 2021-09-14. | ja |
dc.description | Cancer immunotherapy gets PIP boost. 京都大学プレスリリース. 2021-09-14. | en |
dc.description.abstract | Considering the potential of combinatorial therapies in overcoming existing limitations of cancer immunotherapy, there is an increasing need to identify small-molecule modulators of immune cells capable of augmenting the effect of programmed cell death protein 1 (PD-1) blockade, leading to better cancer treatment. Although epigenetic drugs showed potential in combination therapy, the lack of sequence specificity is a major concern. Here, we identify and develop a DNA-based epigenetic activator with tri-arginine vector called EnPGC-1 that can trigger the targeted induction of the peroxisome proliferator-activated receptor-gamma coactivator 1 alpha/beta (PGC-1α/β), a regulator of mitochondrial biogenesis. EnPGC-1 enhances mitochondrial activation, energy metabolism, proliferation of CD8⁺ T cells in vitro, and, in particular, enhances oxidative phosphorylation, a feature of long-lived memory T cells. Genome-wide gene analysis suggests that EnPGC-1 and not the control compounds can regulate T cell activation as a major biological process. EnPGC-1 also synergizes with PD-1 blockade to enhance antitumor immunity and improved host survival. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International 4.0 license. | en |
dc.rights | The full-text file will be made open to the public on 17 March 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | pyrrole-imidazole polyamide | en |
dc.subject | epigenetic activator | en |
dc.subject | PD-1 | en |
dc.subject | cancer immunotherapy | en |
dc.subject | mitochondrial biogenesis | en |
dc.subject | oxidative phosphorylation | en |
dc.subject | T-cell activation | en |
dc.subject | combination therapy | en |
dc.subject | therapeutic gene modulation | en |
dc.title | Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Chemical Biology | en |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 463 | - |
dc.identifier.epage | 475 | - |
dc.relation.doi | 10.1016/j.chembiol.2021.08.001 | - |
dc.textversion | author | - |
dc.identifier.artnum | e6 | - |
dc.address | Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University | en |
dc.address | Institute of Integrated Cell Material Sciences (iCeMS), Kyoto University of Advanced Study | en |
dc.address | Department of Chemistry, Graduate School of Science, Kyoto University | en |
dc.identifier.pmid | 34520746 | - |
dc.relation.url | https://www.icems.kyoto-u.ac.jp/news/4468/ | - |
dc.relation.url | https://www.icems.kyoto-u.ac.jp/en/news/4469/ | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2023-03-17 | - |
datacite.awardNumber | 19H03349 | - |
datacite.awardNumber | 16H06356 | - |
datacite.awardNumber | 20H05936 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03349/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06356/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05936/ | - |
dc.identifier.pissn | 2451-9456 | - |
dc.identifier.eissn | 2451-9448 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 心筋症関連ミトコンドリア・核内遺伝子の協奏的制御を可能にする人工転写因子の開発 | ja |
jpcoar.awardTitle | 人工遺伝子スイッチを用いた遺伝子発現の制御と機構の解明 | ja |
jpcoar.awardTitle | ヌクレオソーム動態のモダリティ | ja |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス