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dc.contributor.author | 大西, 健太 | ja |
dc.contributor.author | 田中, 宣道 | ja |
dc.contributor.author | 堀, 俊太 | ja |
dc.contributor.author | 中井, 靖 | ja |
dc.contributor.author | 三宅, 牧人 | ja |
dc.contributor.author | 穴井, 智 | ja |
dc.contributor.author | 藤本, 清秀 | ja |
dc.contributor.alternative | ONISHI, Kenta | en |
dc.contributor.alternative | TANAKA, Nobumichi | en |
dc.contributor.alternative | HORI, Shunta | en |
dc.contributor.alternative | NAKAI, Yasushi | en |
dc.contributor.alternative | MIYAKE, Makito | en |
dc.contributor.alternative | ANAI, Satoshi | en |
dc.contributor.alternative | FUJIMOTO, Kiyohide | en |
dc.date.accessioned | 2022-08-05T01:53:36Z | - |
dc.date.available | 2022-08-05T01:53:36Z | - |
dc.date.issued | 2022-07-31 | - |
dc.identifier.uri | http://hdl.handle.net/2433/275779 | - |
dc.description | 本論文の要旨は,第109回日本泌尿器科学会総会で発表を行った. | ja |
dc.description.abstract | Sarcopenia is a known predictor of overall survival in several diseases. We investigated the relationship between sarcopenia and outcome of treatment with cabazitaxel (CBZ) for castration-resistant prostate cancer (CRPC) by a retrospective analysis of 37 patients, who were given cabazitaxel at our hospital, from December 2014 to November 2020. The skeletal muscle mass was evaluated using the Psoas Muscle Mass Index (PMI: psoas major muscle area at the level of the third lumber vertebra (cm²)/height x height (m²)) through computed tomography images. The severe sarcopenia group (PMI<4.96) showed lower levels of serum albumin, in comparison with the non-severe sarcopenia group (PMI≥4.96). Multivariate analysis identified PMI (odds ratio=3.7; P=0.023) as an independent factor associated with prostate specific antigen response to CBZ therapy. However, there was no significant difference in the overall survival between the severe and the non-severe sarcopenia groups (P=0.1). Skeletal muscle mass might be closely correlated to the therapeutic response to CBZ, but not to the prognosis of patients with CRPC. Nutritional rehabilitation and exercises targeting sarcopenia for patients with prostate cancer should be considered. | en |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.rights | 許諾条件により本文は2023/08/01に公開 | ja |
dc.subject | Castration-resistant prostate cancer | en |
dc.subject | Cabazitaxel | en |
dc.subject | Sarcopenia | en |
dc.subject.ndc | 494.9 | - |
dc.title | 去勢抵抗性前立腺癌に対するカバジタキセル療法の治療成績とサルコペニアとの関連についての検討 | ja |
dc.title.alternative | The Relationship between Sarcopenia and Survival after Cabazitaxel Treatment for Castration-Resistant Prostate Cancer | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 217 | - |
dc.identifier.epage | 225 | - |
dc.textversion | publisher | - |
dc.sortkey | 02 | - |
dc.address | 奈良県立医科大学泌尿器科; JCHO星ヶ丘医療センター泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address | 奈良県立医科大学泌尿器科 | ja |
dc.address.alternative | The Department of Urology, Nara Medical University; The Department of Urology, Japan Community Healthcare Organization Hoshigaoka Medical Center | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.address.alternative | The Department of Urology, Nara Medical University | en |
dc.identifier.pmid | 35924704 | - |
dc.identifier.selfDOI | 10.14989/ActaUrolJap_68_7_217 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2023-08-01 | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.68 No.7 |
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