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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| asia.202200367.pdf | 3.59 MB | Adobe PDF | 見る/開く |
| タイトル: | Mechanisms and strategies for determining m⁶A RNA modification sites by natural and engineered m⁶A effector proteins |
| 著者: | Imanishi, Miki    https://orcid.org/0000-0002-4172-0966 (unconfirmed) |
| 著者名の別形: | 今西, 未来 |
| キーワード: | RNA methylation RNA recognition N⁶-metyladenosine Protein engineering gene expression |
| 発行日: | 15-Aug-2022 |
| 出版者: | Wiley |
| 誌名: | Chemistry – An Asian Journal |
| 巻: | 17 |
| 号: | 16 |
| 論文番号: | e202200367 |
| 抄録: | N⁶-methyladenosine (m⁶A) is the most common internal RNA modification in the consensus sequence of 5′-RRACH-3′. The methyl mark is added by writer proteins (METTL3/METTL14 metyltransferase complex) and removed by eraser proteins (m⁶A demethylases; FTO and ALKBH5). Recognition of this methyl mark by m⁶A reader proteins leads to changes in RNA metabolism. How the writer and eraser proteins determine their targets is not well-understood, despite the importance of this information in understanding the regulatory mechanisms and physiological roles of m⁶A. However, approaches for targeted manipulation of the methylation state at specific sites are being developed. In this review, I summarize the recent findings on the mechanisms of target identification of m6A regulatory proteins, as well as recent approaches for targeted m⁶A modifications. |
| 著作権等: | This is the peer reviewed version of the following article: [M. Imanishi, Chem. Asian J. 2022, 17, e202200367.], which has been published in final form at https://doi.org/10.1002/asia.202200367. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. The full-text file will be made open to the public on 05 July 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/275878 |
| DOI(出版社版): | 10.1002/asia.202200367 |
| PubMed ID: | 35750635 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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