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2211-5463.13124.pdf | 1.31 MB | Adobe PDF | 見る/開く |
タイトル: | Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein |
著者: | Tanikawa, Kana Kaneko, Kentaro https://orcid.org/0000-0002-5003-2460 (unconfirmed) Abe, Shimon Nakato, Jyunya Tokuyama, Yuki Odaka, Sayano Iwakura, Hiroshi Sato, Masaru Kurabayashi, Atsushi Suzuki, Hideyuki Makita, Miki Ikemoto, Hiroyuki Matsumura, Shigenobu Inoue, Kazuo https://orcid.org/0000-0001-7003-8635 (unconfirmed) Ohinata, Kousaku |
著者名の別形: | 谷川, 加奈 金子, 賢太朗 阿部, 志門 中戸, 絢也 徳山, 雄基 松村, 成暢 井上, 和生 大日向, 耕作 |
キーワード: | comprehensive peptide analysis food intake ghrelin structure–activity relationship wheat peptide |
発行日: | Apr-2021 |
出版者: | Wiley Federation of European Biochemical Societies |
誌名: | FEBS Open Bio |
巻: | 11 |
号: | 4 |
開始ページ: | 1144 |
終了ページ: | 1152 |
抄録: | Ghrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion. We observed that enzymatic digest of wheat gluten stimulated ghrelin secretion from mouse ghrelinoma 3-1, a ghrelin-releasing cell line. Further on, we characterized the ghrelin-releasing peptides present in the digest by comprehensive peptide analysis using liquid chromatography-mass spectrometry and structure-activity relationship. Among the candidate peptides, we found that SQQQQPVLPQQPSF, LSVTSPQQVSY and YPTSL stimulated ghrelin release. We then named them wheat-ghretropin A, B and C, respectively. In addition, we observed that wheat-ghretropin A increased plasma ghrelin concentration and food intake in mice after oral administration. Thus, we demonstrated that wheat-ghretropin stimulates ghrelin release both in vitro and in vivo. To the best of our knowledge, this is the first report of a wheat-derived exogenous bioactive peptide that stimulates ghrelin secretion. |
著作権等: | © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/276524 |
DOI(出版社版): | 10.1002/2211-5463.13124 |
PubMed ID: | 33605550 |
出現コレクション: | 学術雑誌掲載論文等 |
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