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dc.contributor.authorNabeshima, Yukaen
dc.contributor.authorKataoka, Tatsuki R.en
dc.contributor.authorUeshima, Chiyukien
dc.contributor.authorSaito, Narumien
dc.contributor.authorHirata, Masahiroen
dc.contributor.authorTakeuchi, Yasuhideen
dc.contributor.authorTakei, Yusukeen
dc.contributor.authorMoriyoshi, Kokien
dc.contributor.authorOno, Kazuoen
dc.contributor.authorHaga, Hironorien
dc.contributor.alternative鍋島, 優香ja
dc.contributor.alternative片岡, 竜貴ja
dc.contributor.alternative上島, 千幸ja
dc.contributor.alternative平田, 勝啓ja
dc.contributor.alternative竹内, 康英ja
dc.contributor.alternative竹井, 雄介ja
dc.contributor.alternative森吉, 弘毅ja
dc.contributor.alternative羽賀, 博典ja
dc.date.accessioned2022-10-05T03:05:18Z-
dc.date.available2022-10-05T03:05:18Z-
dc.date.issued2021-03-
dc.identifier.urihttp://hdl.handle.net/2433/276572-
dc.description.abstractThe neonatal Fc receptor (FcRn) plays a role in trafficking IgG and albumin and is thought to mediate intravenous immunoglobulin (IVIG) therapy for certain diseases. IVIG can be used for the treatment of human Langerhans cell histiocytosis (LCH); however, the mechanism remains unclear. The expression and function of FcRn protein have not been studied in LCH, though the expression of FcRn messenger RNA (mRNA) have been reported. In this report, we confirmed the expression of FcRn in 26 of 30 pathological cases (86.7%) diagnosed immunohistochemically as LCH. The expression was independent of age, gender, location, multi- or single-system, and the status of BRAFV600E immunostaining. We also confirmed the expression of FcRn mRNA and protein in the human LCH-like cell line, ELD-1. FcRn suppressed albumin consumption and growth of IVIG preparation-treated ELD-1 cells, but not of IVIG preparation-untreated or FcRn-knockdown ELD-1 cells. In addition, FITC-conjugated albumin was taken into Rab11-positive recycle vesicles in mock ELD-1 cells but not in FcRn-knockdown ELD-1 cells. IVIG preparation prolonged this status in mock ELD-1 cells. Therefore, ELD-1 recycled albumin via FcRn and albumin was not used for metabolism. Our results increase our understanding of the molecular mechanism of IVIG treatment of LCH.en
dc.language.isoeng-
dc.publisherWileyen
dc.rights© 2021 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.en
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectalbuminen
dc.subjectcell growthen
dc.subjectintravenous immunoglobulinen
dc.subjectLangerhans cell histiocytosisen
dc.subjectneonatal Fc receptoren
dc.titleNeonatal Fc receptor induces intravenous immunoglobulin growth suppression in Langerhans cell histiocytosisen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitlePathology Internationalen
dc.identifier.volume71-
dc.identifier.issue3-
dc.identifier.spage191-
dc.identifier.epage198-
dc.relation.doi10.1111/pin.13068-
dc.textversionpublisher-
dc.identifier.pmid33497038-
dcterms.accessRightsopen access-
datacite.awardNumber18K07014-
datacite.awardNumber19K16556-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07014/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16556/-
dc.identifier.pissn1320-5463-
dc.identifier.eissn1440-1827-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitleヒト脱落膜マスト細胞のKIR2DL4を介した妊娠成立への関与ja
jpcoar.awardTitleヒト卵管マスト細胞の卵管異所性妊娠発症への関与ja
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