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タイトル: | Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study |
著者: | Minamino, Hiroto Katsushima, Masao Hashimoto, Motomu Fujita, Yoshihito Yoshida, Tamami Ikeda, Kaori https://orcid.org/0000-0003-2273-9693 (unconfirmed) Isomura, Nozomi Oguri, Yasuo https://orcid.org/0000-0002-7435-6961 (unconfirmed) Yamamoto, Wataru Watanabe, Ryu Murakami, Kosaku https://orcid.org/0000-0001-5981-4648 (unconfirmed) Murata, Koichi Nishitani, Kohei https://orcid.org/0000-0002-8327-3826 (unconfirmed) Tanaka, Masao https://orcid.org/0000-0002-8942-2933 (unconfirmed) Ito, Hiromu Ohmura, Koichiro Matsuda, Shuichi Inagaki, Nobuya Morinobu, Akio https://orcid.org/0000-0002-4672-638X (unconfirmed) |
著者名の別形: | 南野, 寛人 勝島, 將夫 橋本, 求 藤田, 義人 吉田, 玉美 池田, 香織 磯村, 望 小栗, 靖生 渡部, 龍 村上, 孝作 村田, 浩一 西谷, 江平 田中, 真生 伊藤, 宣 大村, 浩一郎 松田, 秀一 稲垣, 暢也 森信, 暁雄 |
キーワード: | Urinary sodium-to-potassium ratio Rheumatoid arthritis Disease activity Blood pressure Hypertension |
発行日: | 2021 |
出版者: | Springer Nature BMC |
誌名: | Arthritis Research & Therapy |
巻: | 23 |
論文番号: | 96 |
抄録: | BACKGROUND: Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We performed a cross-sectional study to clarify the associations between salt load index (urinary sodium-to-potassium ratio (Na/K ratio)), current disease activity, and hypertension in an RA population. METHODS: Three hundred thirty-six participants from our cohort database (KURAMA) were enrolled. We used the spot urine Na/K ratio as a simplified index of salt loading and used the 28-Joint RA Disease Activity Score (DAS28-ESR) as an indicator of current RA disease activity. Using these indicators, we evaluated statistical associations between urinary Na/K ratio, DAS28-ESR, and prevalence of hypertension. RESULTS: Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.34, p < 0.001). In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12, p < 0.001), as was also the case in gender-separated and prednisolone-separated sub-analyses. CONCLUSION: Urinary Na/K ratio was independently associated with current disease activity as well as with prevalence of hypertension in RA patients. Thus, dietary modifications such as salt restriction and potassium supplementation should be investigated as a potential candidate for attenuating both disease activity and hypertension in RA patients. |
著作権等: | © The Author(s). 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/276595 |
DOI(出版社版): | 10.1186/s13075-021-02479-x |
PubMed ID: | 33773587 |
出現コレクション: | 学術雑誌掲載論文等 |
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