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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41467-021-23097-w.pdf | 1.23 MB | Adobe PDF | 見る/開く |
| タイトル: | Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia |
| 著者: | Ochi, Yotaro    https://orcid.org/0000-0001-8472-6164 (unconfirmed)Yoshida, Kenichi Huang, Ying-Jung Kuo, Ming-Chung Nannya, Yasuhito Sasaki, Ko Mitani, Kinuko Hosoya, Noriko Hiramoto, Nobuhiro Ishikawa, Takayuki Branford, Susan Shanmuganathan, Naranie Ohyashiki, Kazuma Takahashi, Naoto Takaku, Tomoiku Tsuchiya, Shun Kanemura, Nobuhiro Nakamura, Nobuhiko Ueda, Yasunori Yoshihara, Satoshi Bera, Rabindranath Shiozawa, Yusuke Zhao, Lanying Takeda, June Watatani, Yosaku Okuda, Rurika Makishima, Hideki https://orcid.org/0000-0001-5983-8578 (unconfirmed)Shiraishi, Yuichi Chiba, Kenichi Tanaka, Hiroko Sanada, Masashi Takaori-Kondo, Akifumi Miyano, Satoru Ogawa, Seishi Shih, Lee-Yung |
| 著者名の別形: | 越智, 陽太郎 吉田, 健一 南谷, 泰仁 塩澤, 裕介 趙, 蘭英 竹田, 淳恵 綿谷, 陽作 奥田, 瑠璃花 牧島, 秀樹 髙折, 晃史 小川, 誠司 |
| キーワード: | Cancer genetics Haematological cancer Mutation |
| 発行日: | 2021 |
| 出版者: | Springer Nature |
| 誌名: | Nature Communications |
| 巻: | 12 |
| 論文番号: | 2833 |
| 抄録: | Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML. |
| 著作権等: | © The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/276756 |
| DOI(出版社版): | 10.1038/s41467-021-23097-w |
| PubMed ID: | 33990592 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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