ダウンロード数: 56
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
rme-2021-0049.pdf | 11.64 MB | Adobe PDF | 見る/開く |
タイトル: | Recombinant human FGF-2 for the treatment of early-stage osteonecrosis of the femoral head: TRION, a single-arm, multicenter, Phase II trial |
著者: | Kuroda, Yutaka ![]() ![]() ![]() Tanaka, Takeyuki Miyagawa, Takaki Hamada, Hidetoshi Abe, Hiroyasu ![]() Ito-Ihara, Toshiko Asada, Ryuta Fujimoto, Yusuke Takahashi, Daisuke Tetsunaga, Tomonori Kaneuji, Ayumi Takagi, Michiaki Inaba, Yutaka Morita, Satoshi ![]() ![]() Sugano, Nobuhiko Tanaka, Sakae Matsuda, Shuichi ![]() ![]() Akiyama, Haruhiko |
著者名の別形: | 黒田, 隆 阿部, 寛康 森田, 智視 松田, 秀一 |
キーワード: | avascular necrosis bone regeneration clinical trial core decompression FGF gelatin hydrogel growth factor osteonecrosis of femoral head Phase II regenerative therapy |
発行日: | Jun-2021 |
出版者: | Future Medicine Ltd |
誌名: | Regenerative Medicine |
巻: | 16 |
号: | 6 |
開始ページ: | 535 |
終了ページ: | 548 |
抄録: | Aim: This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis of the femoral head (ONFH). Patients & methods: Sixty-four patients with nontraumatic, precollapse and large ONFHs were percutaneously administered with 800 μg rhFGF-2 contained in gelatin hydrogel. Setting the end point of radiological collapse, we analyzed the joint preservation period of the historical control. Changes in two validated clinical scores, bone regeneration and safety were evaluated. Results: Radiological joint preservation time was significantly higher in the rhFGF-2 group than in the control group. The ONFHs tended to improve to smaller ONFHs. The postoperative clinical scores significantly improved. Thirteen serious adverse events showed recovery. Conclusion: rhFGF-2 treatment increases joint preservation time with clinical efficacy, radiological bone regeneration and safety. |
著作権等: | © 2021 Yutaka Kuroda This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. |
URI: | http://hdl.handle.net/2433/276759 |
DOI(出版社版): | 10.2217/rme-2021-0049 |
PubMed ID: | 34075804 |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス