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タイトル: Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma
著者: Bai, Dan
Feng, Huhu
Yang, Jiajun
Yin, Aiping
Lin, Xiao
Qian, Airong
Sugiyama, Hiroshi
著者名の別形: 杉山, 弘
キーワード: ferroptosis
clear cell renal cell carcinoma
tumor microenvironment
immunotherapy
prognosis
発行日: Sep-2021
出版者: Elsevier BV
誌名: Molecular Therapy - Nucleic Acids
巻: 25
開始ページ: 186
終了ページ: 197
抄録: In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME). On the mRNA expression profiles of 57 ferroptosis-related genes (FRGs), three ferroptosis patterns were constructed, with distinct prognosis and immune cell infiltrations (especially T cells and dendritic cells). The high ferroptosis scores were characterized by poorer prognosis, increased T cell infiltration, higher immune and stromal scores, elevated tumor mutation burden, and enhanced response to anti-CTLA4 immunotherapy. Meanwhile, the low ferroptosis scores were distinctly associated with enhanced tumor purity and amino acid and fatty acid metabolism pathways. Following validation, the ferroptosis score was an independent and effective prognostic factor. Collectively, ferroptosis could be involved in the diverse and complex TME. Evaluation of the ferroptosis patterns may heighten the comprehension about immune infiltrations in the TME, assisting oncologists to generate individualized immunotherapeutic strategies.
著作権等: © 2021 The Author(s).
This is an open access article under the CC BY-NC-ND license.
URI: http://hdl.handle.net/2433/276808
DOI(出版社版): 10.1016/j.omtn.2021.05.009
PubMed ID: 34458004
出現コレクション:学術雑誌掲載論文等

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