Elucidation of Complex Dynamic Intermolecular Interactions in Membranes

Abstract

Biomembranes composed of various proteins and lipids play important roles in cellular functions, such as signal transduction and substance transport. In addition, some bioactive peptides and pathogenic proteins target membrane proteins and lipids to exert their effects. Therefore, an understanding of dynamic and complex intermolecular interactions among these membrane constituents is needed to elucidate their mechanisms. This review summarizes the major research carried out in the author’s laboratory on how lipids and their inhomogeneous distributions regulate the structures and functions of antimicrobial peptides and Alzheimer’s amyloid β-protein. Also, how to detect transmembrane helix–helix and membrane protein–protein interactions and how they are modulated by lipids are discussed.