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タイトル: | Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins |
著者: | Kosugi, Yusuke Uriu, Keiya Suzuki, Narumi Yamamoto, Keisuke Nagaoka, Shumpei Kimura, Izumi Konno, Yoriyuki Aso, Hirofumi Willett, Brian J. Kobayashi, Tomoko Koyanagi, Yoshio https://orcid.org/0000-0002-3007-6642 (unconfirmed) Ueda, Mahoko Takahashi Ito, Jumpei Sato, Kei |
著者名の別形: | 小杉, 優介 山本, 啓輔 長岡, 峻平 木村, 出海 今野, 順介 麻生, 啓文 小柳, 義夫 伊東, 潤平 佐藤, 佳 |
キーワード: | virus evolution FIV Vif APOBEC3 cross-species transmission APOBEC3 |
発行日: | 10-Jun-2021 |
出版者: | American Society for Microbiology |
誌名: | Journal of Virology |
巻: | 95 |
号: | 13 |
論文番号: | e0017821 |
抄録: | As the hosts of lentiviruses, almost 40 species of felids (family Felidae) are distributed around the world, and more than 20 feline species test positive for feline immunodeficiency virus (FIV), a lineage of lentiviruses. These observations suggest that FIVs globally infected a variety of feline species through multiple cross-species transmission events during a million-year history. Cellular restriction factors potentially inhibit lentiviral replication and limit cross-species lentiviral transmission, and cellular APOBEC3 deaminases are known as a potent restriction factor. In contrast, lentiviruses have evolutionary-acquired viral infectivity factor (Vif) to neutralize the APOBEC3-mediated antiviral effect. Because the APOBEC3-Vif interaction is strictly specific for viruses and their hosts, a comprehensive investigation focusing on Vif-APOBEC3 interplay can provide clues that will elucidate the roles of this virus-host interplay on cross-species transmission of lentiviruses. Here, we performed a comprehensive investigation with 144 patterns of a round robin test using 18 feline APOBEC3Z3 genes, an antiviral APOBEC3 gene in felid, and 8 FIV Vifs and derived a matrix showing the interplay between feline APOBEC3Z3 and FIV Vif. We particularly focused on the interplay between the APOBEC3Z3 of three felids (domestic cat, ocelot, and Asian golden cat) and an FIV Vif (strain Petaluma), and revealed that residues 65 and 66 of the APOBEC3Z3 protein of multiple felids are responsible for the counteraction triggered by FIV Petaluma Vif. Altogether, our findings can be a clue to elucidate not only the scenarios of the cross-species transmissions of FIVs in felids but also the evolutionary interaction between mammals and lentiviruses. |
著作権等: | © 2021 Kosugi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
URI: | http://hdl.handle.net/2433/276886 |
DOI(出版社版): | 10.1128/JVI.00178-21 |
PubMed ID: | 33762419 |
出現コレクション: | 学術雑誌掲載論文等 |
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