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Title: Transient Receptor Potential Vanilloid (TRPV) channels: Basal Properties and physiological potential
Authors: Sasase, Tomohiko
Fatchiyah, Fatchiyah
Ohta, Takeshi
Author's alias: 笹瀬, 智彦
太田, 毅
Keywords: TRPV channels
Sensory system
Channel diseases
Drug discovery
Issue Date: 2022
Publisher: AEPress, s.r.o.
Journal title: General physiology and biophysics
Volume: 41
Issue: 3
Start page: 165
End page: 190
Abstract: Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies targeting human diseases. TRPV channels play crucial roles in normal physiological processes, and their dysfunction has been implicated in various disease states. Several small-molecule compounds, such as TRPV1 and TRPV3 antagonists, have been developed as novel analgesic agents. A better understanding of the physiological functions of TRPV channels would lead to progress in life science. In this review, we focus on various functions of TRPV channels, including pain sensing, temperature sensing, and metabolic control, as well as summarize the basal properties and pathophysiological contributions of six TRPV channels. Moreover, we discuss the pharmacological effects of endogenous and exogenous ligands on TRPV channels and related diseases.
Rights: © The Authors 2022.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial 4.0 International License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI(Published Version): 10.4149/gpb_2022016
PubMed ID: 35615999
Appears in Collections:Journal Articles

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