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タイトル: | Influence of vitreomacular interface score on treatment outcomes of anti-VEGF therapy for neovascular age-related macular degeneration |
著者: | Miyata, Manabu https://orcid.org/0000-0002-7574-1749 (unconfirmed) Ooto, Sotaro Yamashiro, Kenji Tamura, Hiroshi https://orcid.org/0000-0002-7740-2732 (unconfirmed) Uji, Akihito Miyake, Masahiro Muraoka, Yuki Takahashi, Ayako Tsujikawa, Akitaka |
著者名の別形: | 宮田, 学 大音, 壮太郎 山城, 健児 田村, 寛 宇治, 彰人 三宅, 正裕 村岡, 勇貴 高橋, 綾子 辻川, 明孝 |
発行日: | 2021 |
出版者: | Springer Nature BMC |
誌名: | International Journal of Retina and Vitreous |
巻: | 7 |
論文番号: | 77 |
抄録: | [Background] To quantitatively evaluate the vitreomacular interface of eyes with neovascular age-related macular degeneration (AMD) and to investigate its association with the 1-year treatment outcome following intravitreal injections of aflibercept (IVA). [Methods] This prospective observational case series included 59 eyes of 59 consecutive patients with treatment-naïve neovascular AMD who were treated with three monthly IVA and subsequent four bi-monthly IVA and were followed up for 1 year. We estimated posterior vitreous detachment at 1, 9, and 25 macular points within an area of 6 × 6 mm2 at the center of the fovea using the built-in enhanced vitreous visualization mode of swept-source optical coherence tomography. One year after the initial IVA, we classified the eyes into either wet or dry groups. [Results] The wet and dry groups included 12 and 47 eyes, respectively. The resistance rate against IVA was 20.3%. The 25-point interface score was higher in the wet group than in the dry group (23.0 ± 4.3 vs. 18.6 ± 9.8, P = 0.03), whereas there were no significant between-group differences in the 9-point and 1-point scores (P = 0.21, and 0.47, respectively) or in the other studied parameters. Multivariable analysis revealed that the 25-point vitreomacular interface score was strongly correlated with subfoveal choroidal thickness (P = 0.02, β = − 0.31). [Conclusions] Our findings suggest that wide-ranged separation of the posterior vitreous membrane from the retina induces poor response to IVA. |
著作権等: | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/277913 |
DOI(出版社版): | 10.1186/s40942-021-00342-4 |
PubMed ID: | 34930502 |
出現コレクション: | 学術雑誌掲載論文等 |
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