ダウンロード数: 24
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
cas.15162.pdf | 2.62 MB | Adobe PDF | 見る/開く |
タイトル: | SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2 |
著者: | Masuo, Kenji Chen, Ru Yogo, Akitada Sugiyama, Aiko Fukuda, Akihisa Masui, Toshihiko Uemoto, Shinji Seno, Hiroshi Takaishi, Shigeo |
著者名の別形: | 増尾, 謙志 陳, 如 余語, 覚匡 杉山, 愛子 福田, 晃久 増井, 俊彦 上本, 伸二 妹尾, 浩 高石, 繁生 |
キーワード: | cancer stem cells epithelial-mesenchymal transition pancreatic cancer SNAIL2 tumor spheroid |
発行日: | Dec-2021 |
出版者: | Wiley |
誌名: | Cancer Science |
巻: | 112 |
号: | 12 |
開始ページ: | 4987 |
終了ページ: | 4999 |
抄録: | Pancreatic cancer has an extremely poor prognosis because of its resistance to conventional therapies. Cancer stem cell (CSC)-targeted therapy is considered a promising approach for this disease. Epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) contribute to CSC properties in some solid tumors; however, this mechanism has not been fully elucidated in pancreatic cancer. Zinc finger protein, SNAIL2 (also known as SLUG), is a member of the SNAIL superfamily of EMT-TFs and is commonly overexpressed in pancreatic cancer. Patients exhibiting high SNAIL2 expression have a poor prognosis. In this study, we showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro (sphere formation assay) and in vivo (xenograft assay) in 2 pancreatic cancer cell lines, KLM1 and KMP5. In addition, SNAIL2 suppression resulted in increased sensitivity to gemcitabine and reduced the expression of CD44, a pancreatic CSC marker. Moreover, experiments on tumor spheroids established from surgically resected pancreatic cancer tissues yielded similar results. A microarray analysis revealed that the mechanism was mediated by insulin-like growth factor (IGF) binding protein 2. These results indicate that IGFBP2 regulated by SNAIL2 may represent an effective therapeutic target for pancreatic cancer. |
著作権等: | © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
URI: | http://hdl.handle.net/2433/277916 |
DOI(出版社版): | 10.1111/cas.15162 |
PubMed ID: | 34628696 |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス