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j.isci.2023.105962.pdf | 6.48 MB | Adobe PDF | 見る/開く |
タイトル: | Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity |
著者: | Coppo, Roberto Kondo, Jumpei Iida, Keita Okada, Mariko Onuma, Kunishige https://orcid.org/0000-0002-1034-5796 (unconfirmed) Tanaka, Yoshihisa Kamada, Mayumi Ohue, Masayuki Kawada, Kenji Obama, Kazutaka https://orcid.org/0000-0003-2924-6701 (unconfirmed) Inoue, Masahiro https://orcid.org/0000-0001-7315-026X (unconfirmed) |
著者名の別形: | 岡田, 眞里子 小沼, 邦重 鎌田, 真由美 大植, 雅之 河田, 健二 小濵, 和貴 井上, 正宏 |
キーワード: | Therapy Cell biology Cancer |
発行日: | 17-Feb-2023 |
出版者: | Elsevier BV |
誌名: | iScience |
巻: | 26 |
号: | 2 |
論文番号: | 105962 |
抄録: | Dynamic changes in cell properties lead to intratumor heterogeneity; however, the mechanisms of nongenetic cellular plasticity remain elusive. When the fate of each cell from colorectal cancer organoids was tracked through a clonogenic growth assay, the cells showed a wide range of growth ability even within the clonal organoids, consisting of distinct subpopulations; the cells generating large spheroids and the cells generating small spheroids. The cells from the small spheroids generated only small spheroids (S-pattern), while the cells from the large spheroids generated both small and large spheroids (D-pattern), both of which were tumorigenic. Transition from the S-pattern to the D-pattern occurred by various extrinsic triggers, in which Notch signaling and Musashi-1 played a key role. The S-pattern spheroids were resistant to chemotherapy and transited to the D-pattern upon drug treatment through Notch signaling. As the transition is linked to the drug resistance, it can be a therapeutic target. |
記述: | 大腸がん細胞の増殖運命の違いと薬剤感受性 --その柔軟性を決めるメカニズム--. 京都大学プレスリリース. 2023-01-20. |
著作権等: | © 2023 The Authors. This is an open access article under the Creative Commons Attribution 4.0 International License. |
URI: | http://hdl.handle.net/2433/278937 |
DOI(出版社版): | 10.1016/j.isci.2023.105962 |
PubMed ID: | 36718360 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2023-01-20 |
出現コレクション: | 学術雑誌掲載論文等 |
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