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タイトル: | Microfabrication of polydimethylsiloxane-parylene hybrid microelectrode array integrated into a multi-organ-on-a-chip |
著者: | Zhang, Dongxiao Yang, Jiandong Hirai, Yoshikazu https://orcid.org/0000-0003-0835-7314 (unconfirmed) Kamei, Ken-ichiro Tabata, Osamu Tsuchiya, Toshiyuki https://orcid.org/0000-0002-7846-5831 (unconfirmed) |
著者名の別形: | 張, 東暁 楊, 建東 平井, 義和 亀井, 謙一郎 田畑, 修 土屋, 智由 |
発行日: | Jan-2023 |
出版者: | IOP Publishing |
誌名: | Japanese Journal of Applied Physics |
巻: | 62 |
号: | 1 |
論文番号: | 017002 |
抄録: | Multi-organ-on-a-chip devices have attracted extensive attention because they hold great potential for advancing drug discovery and development by recapitulating human physiological conditions. However, they often lack on-chip analytical technologies for the in situ non-invasive real-time monitoring of organ tissue responses to pharmaceutical compounds over extended durations. Here, we introduce the microfabrication of a multi-organ-on-a-chip by integrating two indispensable components into a polydimethylsiloxane (PDMS)-based microfluidic device: a pneumatic-actuated micropump to generate a circulation flow for organ-organ interaction and a parylene-insulated microelectrode array (MEA) for electrophysiological analysis. We demonstrated that the pumping performance of the micropump was sufficient for recapitulating the metabolite interaction, and the measured impedance magnitude was comparable to that of state-of-the-art MEA devices. The experimental results suggest that the present microfabrication has potential applications such as the measurement of electrophysiological parameters under recapitulating metabolite interaction, enabling more comprehensive drug testing in vitro. |
著作権等: | This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/aca265. The full-text file will be made open to the public on 15 December 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/278985 |
DOI(出版社版): | 10.35848/1347-4065/aca265 |
出現コレクション: | 学術雑誌掲載論文等 |
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