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このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| MPH.0000000000002482.pdf | 595.43 kB | Adobe PDF | 見る/開く |
| タイトル: | Use of Cabozantinib to Treat MET-amplified Pediatric Colorectal Cancer |
| 著者: | Fukui, Sadahiro Umeda, Katsutsugu   Kubota, Hirohito Iwai, Atsushi Akazawa, Ryo Isobe, Kiyotaka Tanaka, Kuniaki Kouzuki, Kagehiro Kawabata, Naoko Saida, Satoshi Kato, Itaru Hiramatsu, Hidefumi  https://orcid.org/0000-0003-3136-5670 (unconfirmed)Itatani, Yoshiro Funakoshi, Taro Adachi, Souichi Takita, Junko https://orcid.org/0000-0002-2452-6520 (unconfirmed) |
| 著者名の別形: | 福井, 貞弘 梅田, 雄嗣 窪田, 博仁 岩井, 篤 赤澤, 嶺 磯部, 清孝 田中, 邦明 上月, 景弘 川端, 奈央子 才田, 聡 加藤, 格 平松, 英文 板谷, 喜朗 船越, 太郎 足立, 壯一 滝田, 順子 |
| キーワード: | colorectal cancer pediatric cancer gene panel testing MET inhibitor cabozantinib |
| 発行日: | Apr-2023 |
| 出版者: | Wolters Kluwer Health |
| 誌名: | Journal of Pediatric Hematology/Oncology |
| 巻: | 45 |
| 号: | 3 |
| 開始ページ: | e423 |
| 終了ページ: | e426 |
| 抄録: | Pediatric colorectal cancer (CRC) is extremely rare, with little information about genetic profiles compared with adult CRC. Here, a 13-year-old male with advanced CRC underwent cancer gene panel testing, which detected 4 genetic abnormalities (MET amplification in addition to TP53, SMAD4, and CTNNA1 mutations) that might be associated with a poor prognosis. Based on high-level MET amplification, he received a multikinase inhibitor, cabozantinib, after failure of first-line and second-line chemotherapy, resulting in transient disease stabilization. Tailored targeted therapy based on molecular profiling can be an effective treatment strategy for rare cancers such as pediatric CRC. |
| 著作権等: | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Pediatric Hematology/Oncology. The published version of record [Fukui, Sadahiro MD*; Umeda, Katsutsugu MD*; Kubota, Hirohito MD*; Iwai, Atsushi MD*; Akazawa, Ryo MD*; Isobe, Kiyotaka MD*; Tanaka, Kuniaki MD*; Kouzuki, Kagehiro MD*; Kawabata, Naoko MD*; Saida, Satoshi MD*; Kato, Itaru MD*; Hiramatsu, Hidefumi MD*; Itatani, Yoshiro MD†; Funakoshi, Taro MD‡; Adachi, Souichi MD§; Takita, Junko MD*. Use of Cabozantinib to Treat MET-amplified Pediatric Colorectal Cancer. Journal of Pediatric Hematology/Oncology 45(3):p e423-e426, April 2023.] is available online at: https://doi.org/10.1097/MPH.0000000000002482 The full-text file will be made open to the public on 1 April 2024 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/279949 |
| DOI(出版社版): | 10.1097/MPH.0000000000002482 |
| PubMed ID: | 35536994 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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