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タイトル: | Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins |
著者: | Wagatsuma, Takumi Suzuki, Eisuke Shiotsu, Miku Sogo, Akiko Nishito, Yukina Ando, Hideya Hashimoto, Hisashi Petris, Michael J. Kinoshita, Masato https://orcid.org/0000-0003-3936-7371 (unconfirmed) Kambe, Taiho https://orcid.org/0000-0001-9757-063X (unconfirmed) |
著者名の別形: | 我妻, 拓実 鈴木, 英介 塩津, 実久 十河, 暁子 西藤, 有希奈 安藤, 秀哉 橋本, 寿史 木下, 政人 神戸, 大朋 |
キーワード: | Ion transport Metalloproteins Metals |
発行日: | 2023 |
出版者: | Springer Nature |
誌名: | Communications Biology |
巻: | 6 |
論文番号: | 403 |
抄録: | Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in TYRP1 and TYRP2 has not been demonstrated. Here, we report that the expression and function of TYRP1 requires zinc, mediated by ZNT5–ZNT6 heterodimers (ZNT5–6) or ZNT7–ZNT7 homodimers (ZNT7). Loss of ZNT5–6 and ZNT7 function results in hypopigmentation in medaka fish and human melanoma cells, and is accompanied by immature melanosomes and reduced melanin content, as observed in TYRP1 dysfunction. The requirement of ZNT5–6 and ZNT7 for TYRP1 expression is conserved in human, mouse, and chicken orthologs. Our results provide novel insights into the pigmentation process and address questions regarding metalation in tyrosinase protein family. |
記述: | メラニン生合成には、亜鉛も必要だった!. 京都大学プレスリリース. 2023-04-19. |
著作権等: | © The Author(s) 2023 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/281758 |
DOI(出版社版): | 10.1038/s42003-023-04640-5 |
PubMed ID: | 37072620 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2023-04-19 |
出現コレクション: | 学術雑誌掲載論文等 |
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