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タイトル: Mitochondria and G-quadruplex evolution: an intertwined relationship
著者: Sahayasheela, Vinodh J.
Yu, Zutao
Hidaka, Takuya
Pandian, Ganesh N.
Sugiyama, Hiroshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8923-5946 (unconfirmed)
著者名の別形: 余, 祖滔
日髙, 拓也
杉山, 弘
キーワード: G-quadruplexes
mitochondria
evolution
long noncoding RNA
発行日: Jan-2023
出版者: Elsevier BV
誌名: Trends in Genetics
巻: 39
号: 1
開始ページ: 15
終了ページ: 30
抄録: G-quadruplexes (G4s) are non-canonical structures formed in guanine (G)-rich sequences through stacked G tetrads by Hoogsteen hydrogen bonding. Several studies have demonstrated the existence of G4s in the genome of various organisms, including humans, and have proposed that G4s have a regulatory role in various cellular functions. However, little is known regarding the dissemination of G4s in mitochondria. In this review, we report the observation that the number of potential G4-forming sequences in the mitochondrial genome increases with the evolutionary complexity of different species, suggesting that G4s have a beneficial role in higher-order organisms. We also discuss the possible function of G4s in mitochondrial (mt)DNA and long noncoding (lnc)RNA and their role in various biological processes.
著作権等: © 2022 The Authors. Published by Elsevier Ltd.
This is an open access article under the CC BY license.
URI: http://hdl.handle.net/2433/281774
DOI(出版社版): 10.1016/j.tig.2022.10.006
PubMed ID: 36414480
出現コレクション:学術雑誌掲載論文等

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