このアイテムのアクセス数: 114
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.tig.2022.10.006.pdf | 3.57 MB | Adobe PDF | 見る/開く |
タイトル: | Mitochondria and G-quadruplex evolution: an intertwined relationship |
著者: | Sahayasheela, Vinodh J. Yu, Zutao Hidaka, Takuya Pandian, Ganesh N. Sugiyama, Hiroshi ![]() ![]() ![]() |
著者名の別形: | 余, 祖滔 日髙, 拓也 杉山, 弘 |
キーワード: | G-quadruplexes mitochondria evolution long noncoding RNA |
発行日: | Jan-2023 |
出版者: | Elsevier BV |
誌名: | Trends in Genetics |
巻: | 39 |
号: | 1 |
開始ページ: | 15 |
終了ページ: | 30 |
抄録: | G-quadruplexes (G4s) are non-canonical structures formed in guanine (G)-rich sequences through stacked G tetrads by Hoogsteen hydrogen bonding. Several studies have demonstrated the existence of G4s in the genome of various organisms, including humans, and have proposed that G4s have a regulatory role in various cellular functions. However, little is known regarding the dissemination of G4s in mitochondria. In this review, we report the observation that the number of potential G4-forming sequences in the mitochondrial genome increases with the evolutionary complexity of different species, suggesting that G4s have a beneficial role in higher-order organisms. We also discuss the possible function of G4s in mitochondrial (mt)DNA and long noncoding (lnc)RNA and their role in various biological processes. |
著作権等: | © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. |
URI: | http://hdl.handle.net/2433/281774 |
DOI(出版社版): | 10.1016/j.tig.2022.10.006 |
PubMed ID: | 36414480 |
出現コレクション: | 学術雑誌掲載論文等 |

このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス