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タイトル: | Ion-specific nanoscale compaction of cysteine-modified poly(acrylic acid) brushes revealed by 3D scanning force microscopy with frequency modulation detection |
著者: | Yamamoto, Akihisa https://orcid.org/0000-0002-3394-2147 (unconfirmed) Ikarashi, Takahiko Fukuma, Takeshi Suzuki, Ryo https://orcid.org/0000-0002-7603-2194 (unconfirmed) Nakahata, Masaki Miyata, Kazuki Tanaka, Motomu https://orcid.org/0000-0003-3663-9554 (unconfirmed) |
著者名の別形: | 山本, 暁久 鈴木, 量 田中, 求 |
発行日: | 7-Dec-2022 |
出版者: | Royal Society of Chemistry (RSC) |
誌名: | Nanoscale Advances |
巻: | 4 |
号: | 23 |
開始ページ: | 5027 |
終了ページ: | 5036 |
抄録: | Stimuli-responsive polyelectrolyte brushes adapt their physico-chemical properties according to pH and ion concentrations of the solution in contact. We synthesized a poly(acrylic acid) bearing cysteine residues at side chains and a lipid head group at the terminal, and incorporated them into a phospholipid monolayer deposited on a hydrophobic silane monolayer. The ion-specific, nanoscale response of polyelectrolyte brushes was detected by using three-dimensional scanning force microscopy (3D-SFM) combined with frequency modulation detection. The obtained topographic and mechanical landscapes indicated that the brushes were uniformly stretched, undergoing a gradual transition from the brush to the bulk electrolyte in the absence of divalent cations. When 1 mM calcium ions were added, the brushes were uniformly compacted, exhibiting a sharper brush-to-bulk transition. Remarkably, the addition of 1 mM cadmium ions made the brush surface significantly rough and the mechanical landscape highly heterogeneous. Currently, cadmium-specific nanoscale compaction of the brushes is attributed to the coordination of thiol and carboxyl side chains with cadmium ions, as suggested for naturally occurring, heavy metal binding proteins. |
著作権等: | © 2022 The Author(s). Published by the Royal Society of Chemistry This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
URI: | http://hdl.handle.net/2433/281859 |
DOI(出版社版): | 10.1039/d2na00350c |
PubMed ID: | 36504747 |
出現コレクション: | 学術雑誌掲載論文等 |
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