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Title: Accelerator based epithermal neutron source for clinical boron neutron capture therapy
Authors: Hu, Naonori
Tanaka, Hiroki  kyouindb  KAKEN_id
Akita, Kazuhiko
Kakino, Ryo
Aihara, Teruhito
Nihei, Keiji
Ono, Koji
Author's alias: 呼, 尚徳
田中, 浩基
Keywords: BNCT
Cyclotron
neutron detection
Monte Carlo simulation
commissioning
Issue Date: 18-Jan-2023
Publisher: IOS Press
Journal title: Journal of Neutron Research
Volume: 24
Issue: 3-4
Start page: 359
End page: 366
Abstract: The world’s first accelerator based epithermal neutron source for clinical boron neutron capture therapy (BNCT) was designed, developed, and commissioned between 2008 and 2010 by Sumitomo Heavy Industries in collaboration with Kyoto University at the Kyoto University Institute for Integrated Radiation and Nuclear Science. The accelerator system is cyclotron-based and accelerates a proton up to an energy of approximately 30 MeV. The proton strikes a beryllium target, which produces fast neutrons that traverse a beam shaping assembly composed of a combination of lead, iron, aluminum, and calcium fluoride to reduce the neutron energy down to the epithermal range (∼10 keV) suitable for BNCT. The system is designed to produce an epithermal neutron flux of up to 1.4 × 10 9 n · cm − 2 · s − 1 (exiting from the moderator of a 12 cm diameter collimator) with a proton current of 1 mA. In 2017, the same type of accelerator was installed at the Kansai BNCT Medical Center and in March 2020 the system received medical device approval in Japan (Sumitomo Heavy Industries, NeuCure® BNCT system). Soon after, BNCT for unresectable, locally advanced, and recurrent carcinoma of the head and neck region was approved by the Japanese government for reimbursement covered by the national health insurance system.
Rights: © Naonori Hu, et al., 2022. The definitive, peer reviewed and edited version of this article is published in 'Journal of Neutron Research' 24, 3-4, 359-366, 2023, DOI:10.3233/jnr-220037.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/283976
DOI(Published Version): 10.3233/jnr-220037
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