このアイテムのアクセス数: 101
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s42003-022-03917-5.pdf | 6.31 MB | Adobe PDF | 見る/開く |
| タイトル: | A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice |
| 著者: | Hattori, Etsuko Yamamoto Masuda, Tatsuya Mineharu, Yohei    https://orcid.org/0000-0002-6346-3999 (unconfirmed)Mikami, Masamitsu Terada, Yukinori Matsui, Yasuzumi Kubota, Hirohito https://orcid.org/0000-0002-6935-5120 (unconfirmed)Matsuo, Hidemasa Hirata, Masahiro Kataoka, Tatsuki R. Nakahata, Tatsutoshi Ikeda, Shuji Miyamoto, Susumu Sugiyama, Hiroshi https://orcid.org/0000-0001-8923-5946 (unconfirmed)Arakawa, Yoshiki https://orcid.org/0000-0003-4626-4645 (unconfirmed)Kamikubo, Yasuhiko |
| 著者名の別形: | 山本(服部), 悦子 増田, 達哉 峰晴, 陽平 三上, 真充 寺田, 行範 松井, 恭澄 窪田, 博仁 松尾, 英将 平田, 勝啓 片岡, 竜貴 中畑, 龍俊 池田, 修司 宮本, 享 杉山, 弘 荒川, 芳輝 上久保, 靖彦 |
| キーワード: | Drug development Genetic engineering Molecular medicine |
| 発行日: | 2022 |
| 出版者: | Springer Nature |
| 誌名: | Communications Biology |
| 巻: | 5 |
| 論文番号: | 939 |
| 抄録: | Glioblastoma is the most common adult brain tumour, representing a high degree of malignancy. Transcription factors such as RUNX1 are believed to be involved in the malignancy of glioblastoma. RUNX1 functions as an oncogene or tumour suppressor gene with diverse target genes. Details of the effects of RUNX1 on the acquisition of malignancy in glioblastoma remain unclear. Here, we show that RUNX1 downregulates p21 by enhancing expressions of BIRC5 and PIF1, conferring anti-apoptotic properties on glioblastoma. A gene switch-off therapy using alkylating agent-conjugated pyrrole-imidazole polyamides, designed to fit the RUNX1 DNA groove, decreased expression levels of BIRC5 and PIF1 and induced apoptosis and cell cycle arrest via p21. The RUNX1-BIRC5/PIF1-p21 pathway appears to reflect refractory characteristics of glioblastoma and thus holds promise as a therapeutic target. RUNX gene switch-off therapy may represent a novel treatment for glioblastoma. |
| 著作権等: | © The Author(s) 2022, corrected publication 2022 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/284035 |
| DOI(出版社版): | 10.1038/s42003-022-03917-5 |
| PubMed ID: | 36085167 |
| 出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス
