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j.jphs.2022.10.006.pdf | 1.36 MB | Adobe PDF | 見る/開く |
タイトル: | Acetaminophen improves tardive akathisia induced by dopamine D₂ receptor antagonists |
著者: | Nagaoka, Koki Nagayasu, Kazuki https://orcid.org/0000-0002-7438-732X (unconfirmed) Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed) Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
著者名の別形: | 長岡, 巧樹 白川, 久志 永安, 一樹 金子, 周司 |
キーワード: | Acetaminophen Clinical big data Dopamine D₂ receptor Indirect-pathway medium spiny neurons Tardive akathisia |
発行日: | Jan-2023 |
出版者: | Elsevier BV |
誌名: | Journal of Pharmacological Sciences |
巻: | 151 |
号: | 1 |
開始ページ: | 9 |
終了ページ: | 16 |
抄録: | Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D₂ receptor antagonists. In the present study, we analyzed the FDA Adverse Event Reporting System and IBM MarketScan Research Database to find a drug that can be used concomitantly with dopamine D₂ receptor antagonists and still reduce the risk of akathisia. Acetaminophen was determined to be the most effective akathisia-suppressing drug. In an experimental validation of the hypothesis, chronic treatment of rats with haloperidol caused akathisia symptoms, including increased stereotyped behavior and locomotor activity, and decreased immobility time. Acute treatment with acetaminophen significantly attenuated haloperidol-induced akathisia. In the ventral striata of these rats, acetaminophen prevented haloperidol-induced decrease in the number of c-Fos⁺ preproenkephalin⁺ neurons. These results suggest that acetaminophen is effective in suppressing tardive akathisia by activating indirect-pathway medium spiny neurons. |
著作権等: | © 2022 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license. |
URI: | http://hdl.handle.net/2433/284465 |
DOI(出版社版): | 10.1016/j.jphs.2022.10.006 |
PubMed ID: | 36522124 |
出現コレクション: | 学術雑誌掲載論文等 |
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