このアイテムのアクセス数: 82
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.gore.2022.101115.pdf | 3.87 MB | Adobe PDF | 見る/開く |
| タイトル: | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| 著者: | Yoshimura, Kayoko Yamanoi, Koji    https://orcid.org/0000-0002-1240-5422 (unconfirmed)Kanai, Masashi Okunomiya, Asuka Sagae, Yusuke Sunada, Masumi Taki, Mana https://orcid.org/0000-0002-1540-0985 (unconfirmed)Ukita, Masayo Chigusa, Yoshitsugu https://orcid.org/0000-0001-9629-5912 (unconfirmed)Horie, Akihito Yamaguchi, Ken Hamanishi, Junzo https://orcid.org/0000-0002-7750-0623 (unconfirmed)Minamiguchi, Sachiko https://orcid.org/0000-0002-5800-6769 (unconfirmed)Yamamoto, Noboru Muto, Manabu https://orcid.org/0000-0002-3127-8203 (unconfirmed)Mandai, Masaki |
| 著者名の別形: | 吉村, 佳与子 山ノ井, 康二 金井, 雅史 奥宮, 明日香 寒河江, 悠介 砂田, 真澄 滝, 真奈 浮田, 真沙世 千草, 義継 堀江, 昭史 山口, 建 濵西, 潤三 南口, 早智子 武藤, 学 万代, 昌紀 |
| キーワード: | Malignant transformation of mature cystic teratoma Immune checkpoint inhibitor Comprehensive genomic profiling test PD-L1 Tumor mutation burden |
| 発行日: | Dec-2022 |
| 出版者: | Elsevier BV |
| 誌名: | Gynecologic Oncology Reports |
| 巻: | 44 |
| 論文番号: | 101115 |
| 抄録: | Mature cystic teratoma of the ovary (MCT) occasionally undergoes malignant transformation (MT) that is resistant to chemotherapy and has a poor prognosis. We experienced a case of clinically aggressive MCT-MT that invades surrounding organs and tissues. Although tumor was resected entirely, a rapid tumor recurrence occurred during postoperative chemotherapy (paclitaxel + ifosfamide + cisplatin). The results of comprehensive genomic profiling test performed early in the postoperative period showed a high tumor mutational burden of 23 mutations/Mb. Treatment with nivolumab monotherapy has promptly been initiated and has been very successful for more than one year. |
| 著作権等: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. |
| URI: | http://hdl.handle.net/2433/284687 |
| DOI(出版社版): | 10.1016/j.gore.2022.101115 |
| PubMed ID: | 36560959 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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