Access count of this item: 83
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| biophys.63.143.pdf | 1.72 MB | Adobe PDF | View/Open |
| Title: | ブラウンラチェットを介する力の受容器ラメリポディア |
| Other Titles: | Brownian Ratchet-based Force Sensor, Lamellipodium |
| Authors: | 渡邊, 直樹    https://orcid.org/0000-0001-8492-200X (unconfirmed) |
| Author's alias: | WATANABE, Naoki |
| Keywords: | Brownian ratchet lamellipodium actin polymerization traction force sensing cell protrusion information conversion |
| Issue Date: | 2023 |
| Publisher: | 日本生物物理学会 |
| Journal title: | 生物物理 |
| Volume: | 63 |
| Issue: | 3 |
| Start page: | 143 |
| End page: | 147 |
| Abstract: | 細胞先導端のアクチン重合は，押す力を発生する「重合モーター」と考えられてきた．この力の発生を説明するブラウンラチェット機構がラメリポディア先端で稼働するかについて，検証した研究を紹介するとともに，同機構が細胞のメカノセンサーとなり，外力を細胞運動のための情報に変換している可能性について解説する． Our recent live-cell single-molecule analysis revealed the force-velocity relationship of actin polymerization at the lamellipodium tip. Locally-applied traction force enhanced actin polymerization exclusively at the tip, followed by gradual cell protrusion. The results are consistent with the force-velocity curve predicted by the Brownian ratchet theory. In the lamellipodium, the load on each actin barbed end is kept low by the constant retrograde actin flow and densely-packed filaments. This enables fast reactivity of cell edge protrusion against subtle force changes. Cells appear to use the Brownian ratchet mechanism to harness ‘information’ for their force-directed morphogenesis and migration. |
| Rights: | © 2023 by THE BIOPHYSICAL SOCIETY OF JAPAN This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) license. |
| URI: | http://hdl.handle.net/2433/284919 |
| DOI(Published Version): | 10.2142/biophys.63.143 |
| Appears in Collections: | Journal Articles |
This item is licensed under a Creative Commons License
