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タイトル: | Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding |
著者: | Tsuboi, Alice Fujimoto, Koichi Kondo, Takefumi |
著者名の別形: | 坪井, 有寿 藤本, 仰一 近藤, 武史 |
発行日: | Sep-2023 |
出版者: | American Association for the Advancement of Science (AAAS) |
誌名: | Science Advances |
巻: | 9 |
号: | 35 |
論文番号: | eadh2154 |
抄録: | Biological systems are inherently noisy; however, they produce highly stereotyped tissue morphology. Drosophila pupal wings show a highly stereotypic folding through uniform expansion and subsequent buckling of wing epithelium within a surrounding cuticle sac. The folding pattern produced by buckling is generally stochastic; it is thus unclear how buckling leads to stereotypic tissue folding of the wings. We found that the extracellular matrix (ECM) protein, Dumpy, guides the position and direction of buckling-induced folds. Dumpy anchors the wing epithelium to the overlying cuticle at specific tissue positions. Tissue-wide alterations of Dumpy deposition and degradation yielded different buckling patterns. In summary, we propose that spatiotemporal ECM remodeling shapes stereotyped tissue folding through dynamic interactions between the epithelium and its external structures. |
記述: | 細胞シートを3次元に折れたたむ仕組み発見 --接着素材の構築・解体が正確な生体組織の「折り紙」を実現--. 京都大学プレスリリース. 2023-09-04. Unveiling the mechanism of 3D folding of cell sheets: Constructing and disassembling adhesive materials for precise origami of tissues. 京都大学プレスリリース. 2023-09-07. |
著作権等: | Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/284920 |
DOI(出版社版): | 10.1126/sciadv.adh2154 |
PubMed ID: | 37656799 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2023-09-04 https://www.kyoto-u.ac.jp/en/research-news/2023-09-07 |
出現コレクション: | 学術雑誌掲載論文等 |
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