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タイトル: Frequent Transmission of Streptococcus pneumoniae Serotype 35B and 35D, Clonal Complex 558 Lineage, across Continents and the Formation of Multiple Clades in Japan
著者: Shinohara, Koh
Fujisawa, Takao
Chang, Bin
Ito, Yutaka
Suga, Shigeru
Matsumura, Yasufumi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8595-8944 (unconfirmed)
Yamamoto, Masaki  kyouindb  KAKEN_id
Nagao, Miki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8886-6145 (unconfirmed)
Ohnishi, Makoto
Sugai, Motoyuki
Nakano, Satoshi
著者名の別形: 篠原, 浩
松村, 康史
山本, 正樹
長尾, 美紀
中野, 哲志
キーワード: Streptococcus pneumoniae
pneumococcal disease
serotype 35B
serotype 35D
multidrug resistance
whole-genome sequencing
発行日: 16-Feb-2023
出版者: American Society for Microbiology
誌名: Antimicrobial Agents and Chemotherapy
巻: 67
号: 2
論文番号: e01083-22
抄録: Streptococcus pneumoniae is a common bacterial pathogen that causes infections in children worldwide, even after administration of the pneumococcal conjugate vaccine. S. pneumoniae serotype 35B, especially the clonal complex 558 (CC558) lineage, has emerged globally following implementation of the 13-valent pneumococcal conjugate vaccine. Serotype 35B strains are also associated with multidrug resistance to both β-lactams and non-β-lactam drugs. In addition, a novel serotype, 35D, which is closely related to 35B and differs in polysaccharide structure, was recently reported. However, the genetic relationship among globally disseminating serotype 35B and D (35B/D) strains remains unknown. To investigate the molecular epidemiology of global serotype 35B/D strains, we conducted a genomic analysis of serotype 35B/D strains from various continents, including those from the Japanese national surveillance collection. A total of 87 isolates were identified as serotype 35B/D in the Japanese surveillance collection (n = 1, 358). All the isolates were assigned to either CC558 or CC2755. Serotype 35D isolates were interspersed with serotype 35B isolates. Phylogenetic analysis revealed the formation of multiple clusters by the Japanese serotype 35B/D-CC558 isolates among the foreign isolates, which suggested multiple events of introduction of the clone into Japan. The global 35B/D-CC558 strains were found to share specific penicillin-binding protein profiles, pbp1a-4, pbp2b-7, and pbp2x-7, associated with penicillin, cephalosporin, and carbapenem nonsusceptibility. Moreover, 88.5% of the Japanese 35B/D-CC558 and 35B/D-CC2755 isolates were found to harbor the Tn916-like integrative and conjugative elements Tn2009, Tn2010, and Tn6002, associated with multidrug resistance to macrolides and tetracyclines. The results of this study imply that serotype 35B/D-CC558 strains could be frequently transmitted intercontinentally.
著作権等: © 2023 Shinohara et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
URI: http://hdl.handle.net/2433/286144
DOI(出版社版): 10.1128/aac.01083-22
PubMed ID: 36651739
出現コレクション:学術雑誌掲載論文等

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