1. Kyoto University Research Information Repository
2. 002　学位論文
3. 090 博士(工学)

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Permalink : https://doi.org/10.14989/doctor.r13581

タイトル:	Studies of Tricyclic β-lactams as Novel Antimicrobial Agents
その他のタイトル:	新規三環式β-ラクタム系抗生物質の探索研究
著者:	Sato, Jun
著者名の別形:	佐藤, 淳
キーワード:	β-lactam antibiotic tricyclic β-lactam sulfoxide-directed oxidative lactonization carbapenem-resistant Enterobacterale β-lactamase
発行日:	24-Nov-2023
出版者:	Kyoto University
学位授与大学:	京都大学
学位の種類:	新制・論文博士
取得分野:	博士(工学)
報告番号:	乙第13581号
学位記番号:	論工博第4212号
metadata.dc.date.granted:	2023-11-24
請求記号:	新制||工||1990(附属図書館)
論文調査委員:	(主査)教授 松原 誠二郎, 教授 中尾 佳亮, 教授 浦山 健治
学位授与の要件:	学位規則第4条第2項該当
著作権等:	(1) A novel tricyclic β-lactam exhibiting potent antibacterial activities against carbapenem-resistant Enterobacterales: Synthesis and structure-activity-relationships. Jun Sato, Hiroki Kusano, Toshiaki Aoki, Satoru Shibuya, Katsuki Yokoo, Kazuo Komano, Takuya Oguma, Shuhei Matsumoto, Takafumi Sato, Kazuya Yasuo, Kenji Yamawaki Bioorg. Med. Chem. 2021, 46, 116343. Copyright 2021 Elsevier Ltd. Reproduced with permission. To access the final edited and published work, see [https://doi.org/10.1016/j.bmc.2021.116343]. (2) Discovery of a Tricyclic β-Lactam as a Potent Antimicrobial Agent against Carbapenem-Resistant Enterobacterales, Including Strains with Reduced Membrane Permeability and Four-Amino Acid Insertion into Penicillin-Binding Protein 3: Structure–Activity-Relationships and In Vitro and In Vivo Activities. Jun Sato, Hiroki Kusano, Toshiaki Aoki, Satoru Shibuya, Katsuki Yokoo, Kazuo Komano, Takuya Oguma, Shuhei Matsumoto, Rio Nakamura, Takafumi Sato, Kenji Yamawaki ACS Infect. Dis. 2022, 8, 400–410. Copyright 2022 American Chemical Society. Reproduced with permission. To access the final edited and published work, see [https://doi.org/10.1021/acsinfecdis.1c00549]. (3) Stereoselective Synthesis of Tricyclic β‑Lactam by Sulfoxide-Directed Oxidative Lactonization from an Accessible Cephalosporin Intermediate. Jun Sato, Takuya Oguma, Kenji Yamawaki J. Org. Chem. 2022, 87, 11231–11236. Copyright 2022 American Chemical Society. Reproduced with permission. To access the final edited and published work, see [https://doi.org/10.1021/acs.joc.2c01113]. (4) Arylcyanation of Norbornene and Norbornadiene Catalyzed by Nickel. Yoshiaki Nakao, Akira Yada, Jun Satoh, Shiro Ebata, Shinichi Oda, Tamejiro Hiyama Chem. Lett. 2006, 35, 790–791. Copyright 2006 The Chemical Society of Japan. Reproduced with permission. To access the final edited and published work, see [https://doi.org/10.1246/cl.2006.790].
DOI:	10.14989/doctor.r13581
URI:	http://hdl.handle.net/2433/286348
出現コレクション:	090 博士(工学)

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